Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NFE2L2 | Q16236 | 7/20 | 0.39 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 4/20 | 0.38 |
| ▸ | NPC1 | O15118 | 2/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | ATM | Q13315 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.34 |
| ▸ | STAT1 | P42224 | 1/20 | 0.34 |
| ▸ | JAK2 | O60674 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.33 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.33 |
| ▸ | RELA | Q04206 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL732499 | 1.00 | NFE2L2 (0.39) | NFE2L2PTK2RAB9ANPC1L3MBTL1 | |
| SCHEMBL1879690 | 0.80 | EGFR (0.34) | L3MBTL1SMN1; SMN2 | |
| SCHEMBL1879689 | 0.80 | EGFR (0.34) | L3MBTL1SMN1; SMN2 | |
| SCHEMBL27640623 | 0.79 | PTK2 (0.49) | NFE2L2PTK2RAB9ANPC1L3MBTL1 | |
| SCHEMBL1885751 | 0.76 | — | — | |
| SCHEMBL23722448 | 0.70 | PADI4 (0.32) | RAB9ANPC1SMN1; SMN2 | |
| SCHEMBL1219449 | 0.70 | GABRA1 (0.47) | RAB9ANPC1L3MBTL1TDP1SMN1; SMN2 | |
| SCHEMBL1124256 | 0.69 | NFE2L2 (0.49) | NFE2L2PTK2RAB9ANPC1L3MBTL1 | |
| SCHEMBL753041 | 0.69 | NFE2L2 (0.49) | NFE2L2PTK2RAB9ANPC1L3MBTL1 | |
| SCHEMBL14948653 | 0.69 | RAB9A (0.37) | RAB9ANPC1L3MBTL1SMN1; SMN2GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8138188-B2 | Melanocortin type 4 receptor agonist piperidinoylpyrrolidines | PFIZER INC. (US) | 2012-03-20 | — | — | US | disclosed |