Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.78 |
| ▸ | ALOX15 | P16050 | 3/20 | 0.78 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.78 |
| ▸ | LMNA | P02545 | 2/20 | 0.78 |
| ▸ | HSPD1 | P10809 | 2/20 | 0.78 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.78 |
| ▸ | HSPE1 | P61604 | 2/20 | 0.78 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.78 |
| ▸ | AR | P10275 | 1/20 | 0.78 |
| ▸ | TSHR | P16473 | 1/20 | 0.78 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.78 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.78 |
| ▸ | USP2 | O75604 | 1/20 | 0.78 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.78 |
| ▸ | ESR1 | P03372 | 1/20 | 0.78 |
| ▸ | TST | Q16762 | 1/20 | 0.78 |
| ▸ | MAPT | P10636 | 3/20 | 0.68 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.68 |
| ▸ | SREBF1 | P36956 | 1/20 | 0.68 |
| ▸ | VDR | P11473 | 4/20 | 0.64 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| 25-Hydroxyergocalciferol- SCHEMBL15981129 | 1.00 | ALDH1A1 (0.78) | ALDH1A1ALOX15CYP3A4LMNAHSPD1 | |
| 25-Hydroxyergocalciferol- SCHEMBL19469428 | 1.00 | ALDH1A1 (0.78) | ALDH1A1ALOX15CYP3A4LMNAHSPD1 | |
| 25-Hydroxyergocalciferol- SCHEMBL15981131 | 1.00 | ALDH1A1 (0.78) | ALDH1A1ALOX15CYP3A4LMNAHSPD1 | |
| 25-Hydroxyergocalciferol- SCHEMBL10034123 | 1.00 | ALDH1A1 (0.78) | ALDH1A1ALOX15CYP3A4LMNAHSPD1 | |
| 25-Hydroxyergocalciferol- SCHEMBL285346 | 1.00 | ALDH1A1 (0.78) | ALDH1A1ALOX15CYP3A4LMNAHSPD1 | |
| 25-Hydroxyergocalciferol- SCHEMBL9933379 | 1.00 | ALDH1A1 (0.78) | ALDH1A1ALOX15CYP3A4LMNAHSPD1 | |
| 25-Hydroxyergocalciferol- SCHEMBL465799 | 1.00 | ALDH1A1 (0.78) | ALDH1A1ALOX15CYP3A4LMNAHSPD1 | |
| 25-Hydroxyergocalciferol- SCHEMBL12464610 | 1.00 | ALDH1A1 (0.78) | ALDH1A1ALOX15CYP3A4LMNAHSPD1 | |
| 25-Hydroxyergocalciferol- SCHEMBL17274134 | 1.00 | ALDH1A1 (0.78) | ALDH1A1ALOX15CYP3A4LMNAHSPD1 | |
| 25-Hydroxyergocalciferol- SCHEMBL9933381 | 1.00 | ALDH1A1 (0.78) | ALDH1A1ALOX15CYP3A4LMNAHSPD1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 75 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1268415-B1 | 26,27-HOMOLOGATED-20-EPI-2-ALKYL-19-NOR-VITAMIN D COMPOUNDS | WISCONSIN ALUMNI RES FOUND (US) | 2013-05-29 | — | — | EP | disclosed |
| US-20110112056-A1 | Use of Carbon-2-Modified-Vitamin D Analogs to Induce the Formation of New Bone | WISCONSIN ALUMNI RESEARCH FOUNDATION (US) | 2011-05-12 | — | — | US | disclosed |
| US-20100179344-A1 | 2-Alkylidene-18,19-Dinor-Vitamin D Compounds | WISCONSIN ALUMNI RESEARCH FOUNDATION (US) | 2010-07-15 | — | — | US | disclosed |
| US-7713951-B2 | 2-alkylidene-18,19-dinor-vitamin D compounds | WISCONSIN ALUMNI RESEARCH FOUNDATION (US) | 2010-05-11 | — | — | US | disclosed |
| US-20090143342-A1 | 26,27-homologated-20-EPI-2-alkylidene-19-nor-vitamin D compounds | WISCONSIN ALUMNI RESEARCH FOUNDATION OF MADISON | 2009-06-04 | — | — | US | disclosed |
| US-7468361-B2 | 2-ethyl and 2-ethylidene-19-nor-vitamin D compounds | WISCONSIN ALUMNI RESEARCH FOUNDATION (US) | 2008-12-23 | — | — | US | disclosed |
| EP-1494680-B1 | USE OF CARBON-2-MODIFIED-VITAMIN D ANALOGS TO INDUCE THE FORMATION OF NEW BONE | WISCONSIN ALUMNI RES FOUND (US) | 2008-09-03 | — | — | EP | disclosed |
| EP-1286962-B1 | 2-ETHYL AND 2-ETHYLIDENE-19-NOR-VITAMIN D COMPOUNDS | WISCONSIN ALUMNI RES FOUND (US) | 2008-06-25 | — | — | EP | disclosed |
| US-20080032956-A1 | 2-Ethyl and 2-Ethylidene-19-Nor-Vitamin D Compounds | WISCONSIN ALUMNI RESEARCH FOUNDATION (US) | 2008-02-07 | — | — | US | disclosed |
| US-7300925-B2 | 2-ethyl and 2-ethylidene-19-nor-vitamin D compounds | WISCONSIN ALUMNI RESEARCH FOUNDATION (US) | 2007-11-27 | — | — | US | disclosed |
| WO-2001074766-A1 | 2-ALKYLIDENE-19-NOR-VITAMIN D COMPOUNDS AND THEIR THERAPEUTIC USES | WISCONSIN ALUMNI RESEARCH FOUNDATION (US) | 2001-10-11 | — | — | WO | disclosed |
| US-20010025036-A1 | Method of locking 1alpha-OH of vitamin D compounds in axial orientation | HERCULES TECHNOLOGY GROWTH CAPITAL, INC. | 2001-09-27 | — | — | US | disclosed |
| US-6281249-B1 | SELECTIVELY TOSYLATING A DIOL; REACTING WITH AN ACETYLENIC COMPOUND; CATALYTIC HYDROGENATION; OXIDATION | WISCONSIN ALUMNI RESEARCH FOUNDATION | 2001-08-28 | — | — | US | disclosed |
| US-6277837-B1 | TREATMENT OF PSORIASIS, LEUKEMIA, CANCERS, OSTEOPOROSIS | WISCONSIN ALUMNI RESEARCH FOUNDATION | 2001-08-21 | — | — | US | disclosed |
| WO-2001042205-A2 | TREATMENT OF INFLAMMATORY BOWEL DISEASE WITH VITAMIN D COMPOUNDS | THE PENN STATE RESEARCH FOUNDATION (US) | 2001-06-14 | — | — | WO | disclosed |
| EP-1077937-A1 | METHOD OF LOCKING 1$g(a)-OH OF VITAMIN D COMPOUNDS IN AXIAL ORIENTATION | WISCONSIN ALUMNI RESEARCH FOUNDATION (US) | 2001-02-28 | — | — | EP | disclosed |
| EP-0971888-A1 | 2-ALKYL-19-NOR-VITAMIN D COMPOUNDS | WISCONSIN ALUMNI RESEARCH FOUNDATION (US) | 2000-01-19 | — | — | EP | disclosed |
| WO-1999059966-A1 | METHOD OF LOCKING 1α-OH OF VITAMIN D COMPOUNDS IN AXIAL ORIENTATION | WISCONSIN ALUMNI RESEARCH FOUNDATION (US) | 1999-11-25 | — | — | WO | disclosed |
| WO-1999003829-A1 | 18-SUBSTITUTED-19-NOR-VITAMIN D COMPOUNDS | WISCONSIN ALUMNI RESEARCH FOUNDATION (US) | 1999-01-28 | — | — | WO | disclosed |
| WO-1998041500-A1 | 2-ALKYL-19-NOR-VITAMIN D COMPOUNDS | WISCONSIN ALUMNI RESEARCH FOUNDATION (US) | 1998-09-24 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090143342-A1 | 26,27-homologated-20-EPI-2-alkylidene-19-nor-vitamin D compounds | VDR, CYP24A1, CYP2R1 | ALDH1A1 2583/4885ALOX15 1537/4885CYP3A4 1432/4885 |
| US-20080032956-A1 | 2-Ethyl and 2-Ethylidene-19-Nor-Vitamin D Compounds | CYP24A1, VDR, CYP2R1 | ALDH1A1 1830/4885ALOX15 868/4885CYP3A4 436/4885 |
| US-20100179344-A1 | 2-Alkylidene-18,19-Dinor-Vitamin D Compounds | VDR, CD14, CYP24A1 | ALDH1A1 3396/4885ALOX15 1063/4885CYP3A4 2974/4885 |
| US-20110112056-A1 | Use of Carbon-2-Modified-Vitamin D Analogs to Induce the Formation of New Bone | CYP24A1, VDR, CYP2R1 | ALDH1A1 2629/4885ALOX15 1819/4885CYP3A4 377/4885 |
| US-20010025036-A1 | Method of locking 1alpha-OH of vitamin D compounds in axial orientation | CYP24A1, VDR, CYP2R1 | ALDH1A1 2286/4885ALOX15 1121/4885CYP3A4 1124/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.