Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 0.53 |
| ▸ | LMNA | P02545 | 5/20 | 0.53 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.53 |
| ▸ | MEN1 | O00255 | 4/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.53 |
| ▸ | CA1 | P00915 | 3/20 | 0.53 |
| ▸ | CA2 | P00918 | 3/20 | 0.53 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.53 |
| ▸ | ALOX15 | P16050 | 3/20 | 0.53 |
| ▸ | HIF1A | Q16665 | 3/20 | 0.53 |
| ▸ | HPGD | P15428 | 2/20 | 0.53 |
| ▸ | CA12 | O43570 | 2/20 | 0.53 |
| ▸ | CA3 | P07451 | 2/20 | 0.53 |
| ▸ | TYR | P14679 | 2/20 | 0.53 |
| ▸ | CA4 | P22748 | 2/20 | 0.53 |
| ▸ | CA5A | P35218 | 2/20 | 0.53 |
| ▸ | CA9 | Q16790 | 2/20 | 0.53 |
| ▸ | CA14 | Q9ULX7 | 2/20 | 0.53 |
| ▸ | CA5B | Q9Y2D0 | 2/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13351348 | 0.78 | MAPT (0.63) | MAPTLMNAHSD17B10MEN1KMT2A | |
| Hydroquinone SCHEMBL15516 | 0.73 | — | — | |
| Hydroquinone SCHEMBL11511669 | 0.73 | ALOX15 (1.00) | MAPTLMNAHSD17B10MEN1KMT2A | |
| Hydroquinone SCHEMBL460669 | 0.73 | ALOX15 (1.00) | MAPTLMNAHSD17B10MEN1KMT2A | |
| SCHEMBL5341263 | 0.72 | MAPT (0.61) | MAPTLMNAHSD17B10MEN1KMT2A | |
| SCHEMBL70814 | 0.72 | MEN1 (0.67) | MAPTLMNAHSD17B10MEN1KMT2A | |
| SCHEMBL8218963 | 0.71 | ALDH1A1 (0.52) | MAPTLMNAMEN1KMT2AHPGD | |
| SCHEMBL4840434 | 0.69 | — | — | |
| SCHEMBL14098710 | 0.69 | ESR1 (0.62) | MAPTLMNAHSD17B10MEN1KMT2A | |
| Hydroquinone SCHEMBL9857917 | 0.69 | ALOX15 (0.89) | MAPTLMNAHSD17B10MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 19 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1928881-A2 | PRODRUGS OF ACTIVE AGENTS | Pharmacofore, Inc. (US) | 2008-06-11 | — | — | EP | claimed |
| US-20070123468-A1 | Prodrugs of active agents | PHARMACOFORE, INC. | 2007-05-31 | — | — | US | claimed |
| WO-2007022535-A2 | PRODRUGS OF ACTIVE AGENTS | PHARMACOFORE, INC. (US) | 2007-02-22 | — | — | WO | claimed |
| EP-2402037-B1 | CONTROLLED RELEASE OF PHENOLIC OPIOIDS | SIGNATURE THERAPEUTICS INC (US) | 2019-10-23 | — | — | EP | disclosed |
| US-20150148284-A1 | Controlled Release of Phenolic Opioids | PHARMACOFORE, INC. | 2015-05-28 | — | — | US | disclosed |
| US-8921418-B2 | Controlled release of phenolic opioids | SIGNATURE THERAPEUTICS, INC. (US) | 2014-12-30 | — | — | US | disclosed |
| EP-2046393-B1 | CONTROLLED RELEASE OF PHENOLIC OPIOIDS | SIGNATURE THERAPEUTICS INC (US) | 2014-02-12 | — | — | EP | disclosed |
| US-20120270894-A1 | Controlled Release of Phenolic Opioids | 3I, LP | 2012-10-25 | — | — | US | disclosed |
| US-8217005-B2 | Controlled release of phenolic opioids | SIGNATURE THERAPEUTICS, INC. (US) | 2012-07-10 | — | — | US | disclosed |
| US-20120142718-A1 | N-17-Alkylated Prodrugs of Opioids | SIGNATURE THERAPEUTICS, INC. | 2012-06-07 | — | — | US | disclosed |
| US-8163701-B2 | Prodrugs of active agents | SIGNATURE THERAPEUTICS, INC. (US) | 2012-04-24 | — | — | US | disclosed |
| EP-2402037-A1 | Controlled release of phenolic opioids | Pharmacofore, Inc. (US) | 2012-01-04 | — | — | EP | disclosed |
| US-20100035826-A1 | CONTROLLED RELEASE OF PHENOLIC OPIOIDS | Phamacofoce, Inc. (CA) | 2010-02-11 | — | — | US | disclosed |
| EP-2046393-A2 | CONTROLLED RELEASE OF PHENOLIC OPIOIDS | Pharmacofore, Inc. (US) | 2009-04-15 | — | — | EP | disclosed |
| WO-2008101202-A1 | N-17-ALKYLATED PRODRUGS OF OPIOIDS | PHARMACOFORE, INC. (US) | 2008-08-21 | — | — | WO | disclosed |
| EP-1928881-A2 | PRODRUGS OF ACTIVE AGENTS | Pharmacofore, Inc. (US) | 2008-06-11 | — | — | EP | disclosed |
| WO-2007140272-A2 | CONTROLLED RELEASE OF PHENOLIC OPIOIDS | PHARMACOFORE, INC. (US) | 2007-12-06 | — | — | WO | disclosed |
| US-20070123468-A1 | Prodrugs of active agents | PHARMACOFORE, INC. | 2007-05-31 | — | — | US | disclosed |
| WO-2007022535-A2 | PRODRUGS OF ACTIVE AGENTS | PHARMACOFORE, INC. (US) | 2007-02-22 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120270894-A1 | Controlled Release of Phenolic Opioids | OPRK1, OPRM1, OPRD1 | MAPT 2521/4885LMNA 4070/4885HSD17B10 804/4885 |
| US-20150148284-A1 | Controlled Release of Phenolic Opioids | OPRK1, OPRM1, OPRD1 | MAPT 2521/4885LMNA 4070/4885HSD17B10 804/4885 |
| US-20100035826-A1 | CONTROLLED RELEASE OF PHENOLIC OPIOIDS | OPRK1, OPRM1, OPRD1 | MAPT 2521/4885LMNA 4070/4885HSD17B10 804/4885 |
| US-20120142718-A1 | N-17-Alkylated Prodrugs of Opioids | OPRM1, OPRD1, OPRL1 | MAPT 3236/4885LMNA 2758/4885HSD17B10 818/4885 |
| US-20070123468-A1 | Prodrugs of active agents | PAICS, AADAC, NQO1 | MAPT 3235/4885LMNA 3548/4885HSD17B10 2119/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.