Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BTK | Q06187 | 4/20 | 0.52 |
| ▸ | PTPRC | P08575 | 2/20 | 0.40 |
| ▸ | MMP1 | P03956 | 1/20 | 0.40 |
| ▸ | F2 | P00734 | 2/20 | 0.40 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | MAPK14 | Q16539 | 3/20 | 0.39 |
| ▸ | TNK2 | Q07912 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.36 |
| ▸ | TMPRSS15 | P98073 | 1/20 | 0.36 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.36 |
| ▸ | ACACB | O00763 | 1/20 | 0.36 |
| ▸ | ACACA | Q13085 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | MMP13 | P45452 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18800685 | 0.89 | BTK (0.64) | BTKMMP1F2SMN1; SMN2MAPK14 | |
| SCHEMBL18800659 | 0.86 | BTK (0.51) | BTKSMN1; SMN2ALDH1A1 | |
| SCHEMBL16168190 | 0.85 | BTK (0.54) | BTKKDM4EALDH1A1PRSS1MCHR1 | |
| SCHEMBL18800413 | 0.85 | BTK (0.62) | BTKF2SMN1; SMN2ALDH1A1HTT | |
| SCHEMBL16168188 | 0.82 | ALDH1A1 (0.53) | BTKSMN1; SMN2ALDH1A1 | |
| SCHEMBL16168193 | 0.81 | PARP10 (0.51) | BTKF2TNK2PRSS1 | |
| SCHEMBL18800820 | 0.81 | BTK (0.51) | BTKF2SMN1; SMN2ALDH1A1 | |
| SCHEMBL18800407 | 0.80 | F2 (0.49) | BTKF2PRSS1 | |
| SCHEMBL18800779 | 0.80 | XDH (0.47) | BTK | |
| SCHEMBL18800673 | 0.80 | PGR (0.53) | BTKF2PRSS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2789615-B1 | Azaindazoles as Btk kinase modulators and use thereof | BRISTOL MYERS SQUIBB CO (US) | 2017-05-03 | — | — | EP | disclosed |