Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.35 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.35 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.34 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.32 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.32 |
| ▸ | JAK2 | O60674 | 1/20 | 0.31 |
| ▸ | BTK | Q06187 | 2/20 | 0.31 |
| ▸ | SCD | O00767 | 2/20 | 0.31 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18800818 | 0.90 | TNK2 (0.35) | JAK2BTK | |
| SCHEMBL18800783 | 0.87 | — | — | |
| SCHEMBL18800664 | 0.81 | BTK (0.47) | MKNK1MKNK2BTK | |
| SCHEMBL18800829 | 0.76 | TNK2 (0.34) | MAP4K4 | |
| SCHEMBL18800817 | 0.70 | TNK2 (0.52) | BTK | |
| SCHEMBL18800415 | 0.69 | BTK (0.46) | MAP4K4BTKCHEK1 | |
| SCHEMBL18800676 | 0.68 | BTK (0.60) | BTKCHEK1 | |
| SCHEMBL18800710 | 0.68 | ALDH1A1 (0.46) | BTK | |
| SCHEMBL18800692 | 0.68 | TEK (0.35) | MKNK1MKNK2 | |
| SCHEMBL18800828 | 0.68 | KDM4E (0.42) | BTKCHEK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2789615-B1 | Azaindazoles as Btk kinase modulators and use thereof | BRISTOL MYERS SQUIBB CO (US) | 2017-05-03 | — | — | EP | disclosed |