Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TNK2 | Q07912 | 2/20 | 0.34 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.34 |
| ▸ | DDT | P30046 | 1/20 | 0.33 |
| ▸ | SSTR2 | P30874 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | PDE4A | P27815 | 1/20 | 0.32 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.32 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.32 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.32 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.31 |
| ▸ | FEN1 | P39748 | 2/20 | 0.31 |
| ▸ | F2 | P00734 | 2/20 | 0.31 |
| ▸ | F10 | P00742 | 2/20 | 0.31 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.31 |
| ▸ | PRSS2 | P07478 | 1/20 | 0.31 |
| ▸ | F7 | P08709 | 1/20 | 0.31 |
| ▸ | PRSS3 | P35030 | 1/20 | 0.31 |
| ▸ | FYN | P06241 | 1/20 | 0.31 |
| ▸ | PLAU | P00749 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18800692 | 0.90 | TEK (0.35) | F2F10FYNAXL | |
| SCHEMBL18800818 | 0.84 | TNK2 (0.35) | TNK2LMNAGAAPDE4APDE4B | |
| SCHEMBL18800831 | 0.81 | TNK2 (0.50) | TNK2MAP4K4DDTLMNAGAA | |
| SCHEMBL18800654 | 0.76 | MKNK1 (0.35) | MAP4K4 | |
| SCHEMBL18800691 | 0.73 | BTK (0.43) | TNK2F10FYNPLAU | |
| SCHEMBL18800693 | 0.72 | IGF1R (0.46) | TNK2F2F10 | |
| SCHEMBL18800758 | 0.72 | DYRK1A (0.33) | PLAU | |
| SCHEMBL18800755 | 0.70 | TNK2 (0.50) | TNK2MAP4K4F2F10 | |
| SCHEMBL18800767 | 0.70 | RAB9A (0.48) | TNK2MAP4K4F10 | |
| SCHEMBL18800914 | 0.69 | CFD (0.45) | MAP4K4LMNAFYNNR1H4AXL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2789615-B1 | Azaindazoles as Btk kinase modulators and use thereof | BRISTOL MYERS SQUIBB CO (US) | 2017-05-03 | — | — | EP | disclosed |