Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARG | P37231 | 2/20 | 0.43 |
| ▸ | PPARA | Q07869 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.36 |
| ▸ | NPBWR1 | P48145 | 1/20 | 0.36 |
| ▸ | BRD4 | O60885 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | HCRTR1 | O43613 | 2/20 | 0.35 |
| ▸ | HCRTR2 | O43614 | 2/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | SLC37A4 | O43826 | 1/20 | 0.34 |
| ▸ | MPO | P05164 | 2/20 | 0.33 |
| ▸ | LMNA | P02545 | 2/20 | 0.33 |
| ▸ | PKM | P14618 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | PSMD14 | O00487 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18801436 | 0.82 | CYP19A1 (0.39) | KMT2ABRD4ALDH1A1NPC1RAB9A | |
| SCHEMBL1648393 | 0.80 | KAT6A (0.40) | KMT2ANPBWR1MEN1ALDH1A1MAPT | |
| SCHEMBL18801417 | 0.77 | KMT2A (0.44) | PPARGPPARAKMT2AMEN1ALDH1A1 | |
| SCHEMBL18801282 | 0.76 | KMT2A (0.43) | PPARGPPARAKMT2AMEN1ALDH1A1 | |
| SCHEMBL18801137 | 0.75 | KMT2A (0.43) | KMT2AMEN1ALDH1A1MAPTNPC1 | |
| SCHEMBL18801059 | 0.74 | KMT2A (0.42) | KMT2AMEN1ALDH1A1MAPTNPC1 | |
| SCHEMBL18801035 | 0.72 | KMT2A (0.43) | KMT2AMEN1ALDH1A1MAPTNPC1 | |
| SCHEMBL18801280 | 0.71 | KMT2A (0.39) | PPARGPPARAKMT2AMEN1ALDH1A1 | |
| SCHEMBL18801149 | 0.70 | L3MBTL1 (0.39) | KMT2AMEN1ALDH1A1NPC1RAB9A | |
| SCHEMBL18801305 | 0.69 | METAP2 (0.54) | KMT2AMEN1ALDH1A1MAPTNPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2486004-B1 | SULPHONE COMPOUNDS FOR USE IN THE TREATMENT OF OBESITY | ZAFGEN INC (US) | 2017-05-03 | — | — | EP | disclosed |