Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.35 |
| ▸ | DRD3 | P35462 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | TUBB4A | P04350 | 1/20 | 0.34 |
| ▸ | TUBB | P07437 | 1/20 | 0.34 |
| ▸ | TUBA3C | P0DPH7 | 1/20 | 0.34 |
| ▸ | TUBA1B | P68363 | 1/20 | 0.34 |
| ▸ | TUBA4A | P68366 | 1/20 | 0.34 |
| ▸ | TUBB4B | P68371 | 1/20 | 0.34 |
| ▸ | TUBB3 | Q13509 | 1/20 | 0.34 |
| ▸ | TUBB2A | Q13885 | 1/20 | 0.34 |
| ▸ | TUBB8 | Q3ZCM7 | 1/20 | 0.34 |
| ▸ | TUBA3E | Q6PEY2 | 1/20 | 0.34 |
| ▸ | TUBA1A | Q71U36 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18801127 | 0.83 | MEN1 (0.36) | SMN1; SMN2GAATSHRDRD3KDM4E | |
| SCHEMBL18801177 | 0.82 | MEN1 (0.36) | SMN1; SMN2GAATSHRKDM4EALDH1A1 | |
| SCHEMBL18801182 | 0.80 | MEN1 (0.39) | SMN1; SMN2GAATSHRKDM4EALDH1A1 | |
| SCHEMBL18801468 | 0.80 | LMNA (0.37) | SMN1; SMN2POLBGAATSHRDRD3 | |
| SCHEMBL1648427 | 0.76 | ALDH1A1 (0.49) | SMN1; SMN2POLBTSHRKDM4EALDH1A1 | |
| SCHEMBL18801342 | 0.75 | ALDH1A1 (0.36) | SMN1; SMN2POLBALDH1A1TUBB4ATUBB | |
| SCHEMBL18801069 | 0.75 | KDM4E (0.32) | GAAKDM4EALDH1A1HPGDLMNA | |
| SCHEMBL1648899 | 0.75 | METAP2 (0.38) | SMN1; SMN2POLBGAATSHRGRM4 | |
| SCHEMBL18801352 | 0.74 | NPSR1 (0.35) | SMN1; SMN2GAAKDM4EHPGDL3MBTL1 | |
| SCHEMBL30004264 | 0.71 | MEN1 (0.40) | SMN1; SMN2POLBTSHRDRD3KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2486004-B1 | SULPHONE COMPOUNDS FOR USE IN THE TREATMENT OF OBESITY | ZAFGEN INC (US) | 2017-05-03 | — | — | EP | disclosed |