Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.37 |
| ▸ | MAPT | P10636 | 3/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 3/20 | 0.37 |
| ▸ | RAB9A | P51151 | 3/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.35 |
| ▸ | PKM | P14618 | 1/20 | 0.35 |
| ▸ | MEP1B | Q16820 | 1/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.34 |
| ▸ | DRD2 | P14416 | 1/20 | 0.33 |
| ▸ | DRD3 | P35462 | 1/20 | 0.33 |
| ▸ | TOP1 | P11387 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18801177 | 0.91 | MEN1 (0.36) | LMNAMAPTSMN1; SMN2GAATSHR | |
| SCHEMBL18801182 | 0.89 | MEN1 (0.39) | LMNAMAPTSMN1; SMN2GAATSHR | |
| SCHEMBL18801127 | 0.85 | MEN1 (0.36) | LMNAMAPTSMN1; SMN2GAATSHR | |
| SCHEMBL18801069 | 0.83 | KDM4E (0.32) | LMNAGAAHPGD | |
| SCHEMBL18801352 | 0.80 | NPSR1 (0.35) | LMNAMAPTSMN1; SMN2GAAKMT2A | |
| SCHEMBL18801337 | 0.80 | SMN1; SMN2 (0.37) | LMNAPOLBSMN1; SMN2GAATSHR | |
| SCHEMBL18801456 | 0.79 | METAP2 (0.40) | LMNAMAPTSMN1; SMN2GAATSHR | |
| SCHEMBL18801342 | 0.77 | ALDH1A1 (0.36) | LMNAMAPTPOLBSMN1; SMN2NPC1 | |
| SCHEMBL1648309 | 0.76 | LMNA (0.40) | LMNAMAPTSMN1; SMN2GAATSHR | |
| SCHEMBL6844882 | 0.75 | LMNA (0.37) | LMNAMAPTSMN1; SMN2GAATSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2486004-B1 | SULPHONE COMPOUNDS FOR USE IN THE TREATMENT OF OBESITY | ZAFGEN INC (US) | 2017-05-03 | — | — | EP | disclosed |