Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABCG2 | Q9UNQ0 | 8/20 | 0.42 |
| ▸ | ABCB1 | P08183 | 3/20 | 0.38 |
| ▸ | SYK | P43405 | 1/20 | 0.38 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.37 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.37 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
| ▸ | EGFR | P00533 | 1/20 | 0.37 |
| ▸ | KDR | P35968 | 1/20 | 0.37 |
| ▸ | IKBKB | O14920 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | DHODH | Q02127 | 1/20 | 0.35 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2469218 | 0.80 | HSD17B10 (0.39) | ABCG2IKBKBMAPTDHODH | |
| SCHEMBL1741981 | 0.73 | KCNH2 (0.55) | ABCG2ABCB1SYKKCNH2SCN5A | |
| SCHEMBL16227778 | 0.69 | ABCG2 (0.57) | ABCG2ABCB1KDRHSD11B1 | |
| SCHEMBL5118835 | 0.68 | ABCG2 (0.40) | ABCG2ABCB1EGFRKDRMAPT | |
| SCHEMBL395539 | 0.68 | CA2 (0.52) | ABCG2ABCB1SYKEGFRKDR | |
| SCHEMBL23319512 | 0.66 | ABCG2 (0.50) | ABCG2SYKCYP1A2CYP3A4CYP2D6 | |
| SCHEMBL15159901 | 0.66 | ABCG2 (0.50) | ABCG2ABCB1IKBKBHSD11B1 | |
| SCHEMBL10094595 | 0.66 | NPC1 (0.51) | ABCG2SYKCYP1A2CYP3A4CYP2D6 | |
| SCHEMBL4807750 | 0.66 | CA12 (0.57) | ABCG2SYKKCNH2SCN5ASCN9A | |
| SCHEMBL6801519 | 0.65 | LRRK2 (0.56) | ABCG2ABCB1SYKKCNH2SCN5A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1853567-B1 | HIV INHIBITING 2-(4-CYANOPHENYLAMINO) PYRIMIDINE OXIDE DERIVATIVES | JANSSEN R & D IRELAND (IE) | 2014-12-31 | — | — | EP | disclosed |
| US-7935711-B2 | HIV inhibiting 2-(4-cyanophenylamino) pyrimidine oxide derivatives | TIBOTEC PHARMACEUTICALS LTD. (IE) | 2011-05-03 | — | — | US | disclosed |
| CN-101119976-B | HIV inhibiting 2-(4-cyanophenylamino) pyrimidine oxide derivatives | TIBOTEC PHARM LTD | 2010-12-22 | — | — | CN | disclosed |
| US-20080194602-A1 | Hiv Inhibiting 2-(4-Cyanophenylamino) Pyrimidine Oxide Derivatives | SONY CORPORATION (JP) | 2008-08-14 | — | — | US | disclosed |
| CN-101119976-A | HIV inhibiting 2-(4-cyanophenylamino) pyrimidine oxide derivatives | TIBOTEC PHARM LTD (IE) | 2008-02-06 | — | — | CN | disclosed |
| EP-1853567-A1 | HIV INHIBITING 2-(4-CYANOPHENYLAMINO) PYRIMIDINE OXIDE DERIVATIVES | Tibotec Pharmaceuticals Ltd. (IE) | 2007-11-14 | — | — | EP | disclosed |
| EP-1853567-A1 | HIV INHIBITING 2-(4-CYANOPHENYLAMINO) PYRIMIDINE OXIDE DERIVATIVES | Tibotec Pharmaceuticals Ltd. (IE) | 2007-11-14 | — | — | EP | disclosed |
| WO-2006087387-A1 | HIV INHIBITING 2-(4-CYANOPHENYLAMINO) PYRIMIDINE OXIDE DERIVATIVES | TIBOTEC PHARMACEUTICALS LTD. (IE) | 2006-08-24 | — | — | WO | disclosed |
| WO-2006087387-A1 | HIV INHIBITING 2-(4-CYANOPHENYLAMINO) PYRIMIDINE OXIDE DERIVATIVES | TIBOTEC PHARMACEUTICALS LTD. (IE) | 2006-08-24 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080194602-A1 | Hiv Inhibiting 2-(4-Cyanophenylamino) Pyrimidine Oxide Derivatives | RTF2, SAMHD1, NUDT1 | ABCG2 616/4885ABCB1 378/4885SYK 4528/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.