Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DHFR | P00374 | 1/20 | 0.87 |
| ▸ | MTHFD1 | P11586 | 3/20 | 0.70 |
| ▸ | LMNA | P02545 | 1/20 | 0.69 |
| ▸ | SOST | Q9BQB4 | 1/20 | 0.66 |
| ▸ | MTHFD2 | P13995 | 3/20 | 0.61 |
| ▸ | FPGS | Q05932 | 2/20 | 0.59 |
| ▸ | TYMS | P04818 | 1/20 | 0.55 |
| ▸ | GART | P22102 | 5/20 | 0.54 |
| ▸ | ATIC | P31939 | 2/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13418314 | 1.00 | DHFR (0.87) | DHFRMTHFD1LMNASOSTMTHFD2 | |
| SCHEMBL258924 | 1.00 | DHFR (0.87) | DHFRMTHFD1LMNASOSTMTHFD2 | |
| SCHEMBL29616604 | 1.00 | DHFR (0.87) | DHFRMTHFD1LMNASOSTMTHFD2 | |
| SCHEMBL3181068 | 1.00 | DHFR (0.87) | DHFRMTHFD1LMNASOSTMTHFD2 | |
| Leucovorin SCHEMBL3031362 | 0.93 | DHFR (1.00) | DHFRMTHFD1LMNASOSTMTHFD2 | |
| Folinic Acid SCHEMBL29616563 | 0.93 | DHFR (1.00) | DHFRMTHFD1LMNASOSTMTHFD2 | |
| Folinic Acid SCHEMBL21498299 | 0.93 | DHFR (1.00) | DHFRMTHFD1LMNASOSTMTHFD2 | |
| Leucovorin SCHEMBL29385578 | 0.93 | DHFR (1.00) | DHFRMTHFD1LMNASOSTMTHFD2 | |
| Leucovorin SCHEMBL36113 | 0.93 | DHFR (1.00) | DHFRMTHFD1LMNASOSTMTHFD2 | |
| Leucovorin SCHEMBL29379632 | 0.93 | DHFR (1.00) | DHFRMTHFD1LMNASOSTMTHFD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 137 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20240415837-A1 | PHARMACOLOGIC MODULATION OF 5-FLUOROURACIL BY FOLINIC ACID AND VITAMIN B6 FOR THE TREATMENT OF PATIENTS WITH CARCINOMA | MACHOVER DAVID (FR) | 2024-12-19 | — | — | US | claimed |
| US-20210213020-A1 | METHODS AND PHARMACEUTICAL COMPOSITIONS FOR TREATING CANCER | INSERM INSTITUT NAT DE LA SANTE ET DE LA RECHIRCHE MEDICALE (FR) | 2021-07-15 | — | — | US | claimed |
| EP-3801513-A1 | METHODS AND PHARMACEUTICAL COMPOSITIONS FOR TREATING CANCER | Machover, David (FR) | 2021-04-14 | — | — | EP | claimed |
| US-20210085685-A1 | Methods of Preventing or Treating Disease States Related to Certain Metabolic Abnormalities | GLOBAL HEALTHCARE FOCUS, LLC | 2021-03-25 | — | — | US | claimed |
| WO-2019229115-A1 | METHODS AND PHARMACEUTICAL COMPOSITIONS FOR TREATING CANCER | INSERM (Institut National de la Santé et de la Recherche Médicale) (FR) | 2019-12-05 | — | — | WO | claimed |
| US-10357496-B2 | Methods, formulations, and kits for rapidly repleting folate levels in women | SOUTH ALABAMA MEDICAL SCIENCE FOUNDATION (US) | 2019-07-23 | — | — | US | claimed |
| US-20180237781-A1 | COMPOSITIONS AND METHODS FOR REGULATION OF GENE EXPRESSION WITH, AND DETECTION OF, FOLINIC ACID AND FOLATES | THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY (US) | 2018-08-23 | — | — | US | claimed |
| EP-3027178-A2 | STABILIZED MODIFIED RELEASE FOLIC ACID DERIVATIVE COMPOSITION, ITS THERAPEUTIC USE AND METHODS OF MANUFACTURE | Adare Pharmaceuticals, Inc. (US) | 2016-06-08 | — | — | EP | claimed |
| WO-2016025750-A2 | COMPOSITIONS AND METHODS FOR REGULATION OF GENE EXPRESSION WITH, AND DETECTION OF, FOLINIC ACID AND FOLATES | THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY (US) | 2016-02-18 | — | — | WO | claimed |
| WO-2015017423-A2 | STABILIZED MODIFIED RELEASE FOLIC ACID DERIVATIVE COMPOSITION, ITS THERAPEUTIC USE AND METHODS OF MANUFACTURE | APTALIS PHARMATECH, INC. (US) | 2015-02-05 | — | — | WO | claimed |
| EP-1912641-A4 | METHODS AND COMPOSITIONS CONTAINING NATURAL FOLATES FOR PROTECTING AGAINST RADIATION DAMAGE | UNIV SOUTH ALABAMA (US) | 2008-12-31 | — | — | EP | claimed |
| WO-2008137043-A1 | METHODS AND COMPOSITIONS | SOUTH ALABAMA MEDICAL SCIENCE FOUNDATION (US) | 2008-11-13 | — | — | WO | claimed |
| EP-1912641-A2 | METHODS AND COMPOSITIONS CONTAINING NATURAL FOLATES FOR PROTECTING AGAINST RADIATION DAMAGE | South Alabama Medical Science Foundation (US) | 2008-04-23 | — | — | EP | claimed |
| WO-2007002356-A2 | METHODS AND COMPOSITIONS CONTAINING NATURAL FOLATES FOR PROTECTING AGAINST RADIATION DAMAGE | SOUTH ALABAMA MEDICAL SCIENCE FOUNDATION (US) | 2007-01-04 | — | — | WO | claimed |
| WO-2006119589-A2 | PREVENTION AND THERAPY OF CEREBRAL FOLATE DEFICIENCY | RAMAEKERS, VINCENT (BE) | 2006-11-16 | — | — | WO | claimed |
| US-6921754-B2 | Human and animal nutrition and dietary supplementation | BASF AKTIENGESELLSCHAFT (DE) | 2005-07-26 | — | — | US | claimed |
| US-20030143304-A1 | Human and animal nutrition and dietary supplementation | BASF AKTIENGESELLSCHAFT (DE) | 2003-07-31 | — | — | US | claimed |
| EP-1282366-A2 | COMPOSITIONS CONTAINING FOLIC ACID AND REDUCED FOLATE | BASF AKTIENGESELLSCHAFT (DE) | 2003-02-12 | — | — | EP | claimed |
| WO-2001084962-A2 | COMPOSITIONS CONTAINING FOLIC ACID AND REDUCED FOLATE | BASF AKTIENGESELLSCHAFT (DE) | 2001-11-15 | — | — | WO | claimed |
| US-5800979-A | Gas chromatography/mass spectrometric determination of folic acid coenzymes | KOLHOUSE J FRED (US) | 1998-09-01 | — | — | US | claimed |