SCHEMBL3181068

SCHEMBL3181068

N=CN1c2c(nc(N)[nH]c2=O)NC[C@H]1CNc1ccc(C(=O)NC(CCC(=O)O)C(=O)O)cc1

nearest known ligand 0.87

Predicted protein targets (top 9)

geneUniProtsupporting neighboursconfidence
DHFR P00374 1/20 0.87
MTHFD1 P11586 3/20 0.70
LMNA P02545 1/20 0.69
SOST Q9BQB4 1/20 0.66
MTHFD2 P13995 3/20 0.61
FPGS Q05932 2/20 0.59
TYMS P04818 1/20 0.55
GART P22102 5/20 0.54
ATIC P31939 2/20 0.54

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL13418314 1.00 DHFR (0.87) DHFRMTHFD1LMNASOSTMTHFD2
SCHEMBL258924 1.00 DHFR (0.87) DHFRMTHFD1LMNASOSTMTHFD2
SCHEMBL29616604 1.00 DHFR (0.87) DHFRMTHFD1LMNASOSTMTHFD2
SCHEMBL188064 1.00 DHFR (0.87) DHFRMTHFD1LMNASOSTMTHFD2
Leucovorin SCHEMBL3031362 0.93 DHFR (1.00) DHFRMTHFD1LMNASOSTMTHFD2
Folinic Acid SCHEMBL29616563 0.93 DHFR (1.00) DHFRMTHFD1LMNASOSTMTHFD2
Folinic Acid SCHEMBL21498299 0.93 DHFR (1.00) DHFRMTHFD1LMNASOSTMTHFD2
Leucovorin SCHEMBL29385578 0.93 DHFR (1.00) DHFRMTHFD1LMNASOSTMTHFD2
Leucovorin SCHEMBL36113 0.93 DHFR (1.00) DHFRMTHFD1LMNASOSTMTHFD2
Leucovorin SCHEMBL29379632 0.93 DHFR (1.00) DHFRMTHFD1LMNASOSTMTHFD2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 50 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6808725-B2 FOOD ADDITIVE SOUTH ALABAMA MEDICAL SCIENCE FOUNDATION 2004-10-26 US claimed
EP-1425978-A1 Food and vitamin preparations containing the natural isomer of reduced folates South Alabama Medical Science Foundation (US) 2004-06-09 EP claimed
EP-0877563-B1 FOOD AND VITAMIN PREPARATIONS CONTAINING THE NATURAL ISOMER OF REDUCED FOLATES UNIV SOUTH ALABAMA (US) 2004-03-31 EP claimed
US-20020176912-A1 Food and vitamin preparations containing the natural isomer of reduced folates SOUTH ALABAMA MEDICAL SCIENCE FOUNDATION 2002-11-28 US claimed
US-20020150653-A1 Food and vitamin preparations containing the natural isomer of reduced folates SOUTH ALABAMA MEDICAL SCIENCE FOUNDATION 2002-10-17 US claimed
US-20010046533-A1 METHOD FOR TREATING A SUBJECT AFFLICTED WITH INTESTINAL MALABSORPTION SOUTH ALABAMA MEDICAL SCIENCE FOUNDATION 2001-11-29 US claimed
US-5997915-A NATURAL ISOMERS OF TETRAHYDROFOLIC ACID DERIVATIVES SOUTH ALABAMA MEDICAL SCIENCE FOUNDATION (US) 1999-12-07 US claimed
EP-0877563-A4 FOOD AND VITAMIN PREPARATIONS CONTAINING THE NATURAL ISOMER OF REDUCED FOLATES UNIV SOUTH ALABAMA (US) 1999-06-09 EP claimed
EP-0877563-A1 FOOD AND VITAMIN PREPARATIONS CONTAINING THE NATURAL ISOMER OF REDUCED FOLATES South Alabama Medical Science Foundation (US) 1998-11-18 EP claimed
WO-1997027764-A1 FOOD AND VITAMIN PREPARATIONS CONTAINING THE NATURAL ISOMER OF REDUCED FOLATES SOUTH ALABAMA MEDICAL SCIENCE FOUNDATION (US) 1997-08-07 WO claimed
EP-2773355-B1 METHODS, FORMULATIONS, AND KITS FOR RAPIDLY REPLETING FOLATE LEVELS IN WOMEN SOUTH ALABAMA MEDICAL SCIENCE FOUND (US) 2022-06-08 EP disclosed
US-10357496-B2 Methods, formulations, and kits for rapidly repleting folate levels in women SOUTH ALABAMA MEDICAL SCIENCE FOUNDATION (US) 2019-07-23 US disclosed
US-10265343-B2 Kits and methods for nutrition supplementation EXELTIS USA, INC. (US) 2019-04-23 US disclosed
US-9895328-B2 Calcium formate as a supplement to prevent neural tube defects BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (US) 2018-02-20 US disclosed
US-20180008634-A1 KITS AND METHODS FOR NUTRITION SUPPLEMENTATION EXELTIS USA, INC. (US) 2018-01-11 US disclosed
US-6254904-B1 COMPRISING: (6S)-TETRAHYDROFOLIC ACID AND DERIVATIVES AND POLYGLUTAMYL DERIVATIVES; MULTIVITAMIN BREAKFAST FOODS, INFANT FORMULAS, DIETARY SUPPLEMENTS AND ANIMAL FEED PREPARATION SOUTH ALABAMA MEDICAL SCIENCE FOUNDATION 2001-07-03 US disclosed
US-5997915-A NATURAL ISOMERS OF TETRAHYDROFOLIC ACID DERIVATIVES SOUTH ALABAMA MEDICAL SCIENCE FOUNDATION (US) 1999-12-07 US disclosed
EP-0877563-A4 FOOD AND VITAMIN PREPARATIONS CONTAINING THE NATURAL ISOMER OF REDUCED FOLATES UNIV SOUTH ALABAMA (US) 1999-06-09 EP disclosed
EP-0877563-A1 FOOD AND VITAMIN PREPARATIONS CONTAINING THE NATURAL ISOMER OF REDUCED FOLATES South Alabama Medical Science Foundation (US) 1998-11-18 EP disclosed
WO-1997027764-A1 FOOD AND VITAMIN PREPARATIONS CONTAINING THE NATURAL ISOMER OF REDUCED FOLATES SOUTH ALABAMA MEDICAL SCIENCE FOUNDATION (US) 1997-08-07 WO disclosed