Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DHFR | P00374 | 1/20 | 0.87 |
| ▸ | MTHFD1 | P11586 | 3/20 | 0.70 |
| ▸ | LMNA | P02545 | 1/20 | 0.69 |
| ▸ | SOST | Q9BQB4 | 1/20 | 0.66 |
| ▸ | MTHFD2 | P13995 | 3/20 | 0.61 |
| ▸ | FPGS | Q05932 | 2/20 | 0.59 |
| ▸ | TYMS | P04818 | 1/20 | 0.55 |
| ▸ | GART | P22102 | 5/20 | 0.54 |
| ▸ | ATIC | P31939 | 2/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13418314 | 1.00 | DHFR (0.87) | DHFRMTHFD1LMNASOSTMTHFD2 | |
| SCHEMBL258924 | 1.00 | DHFR (0.87) | DHFRMTHFD1LMNASOSTMTHFD2 | |
| SCHEMBL188064 | 1.00 | DHFR (0.87) | DHFRMTHFD1LMNASOSTMTHFD2 | |
| SCHEMBL3181068 | 1.00 | DHFR (0.87) | DHFRMTHFD1LMNASOSTMTHFD2 | |
| Leucovorin SCHEMBL3031362 | 0.93 | DHFR (1.00) | DHFRMTHFD1LMNASOSTMTHFD2 | |
| Folinic Acid SCHEMBL29616563 | 0.93 | DHFR (1.00) | DHFRMTHFD1LMNASOSTMTHFD2 | |
| Folinic Acid SCHEMBL21498299 | 0.93 | DHFR (1.00) | DHFRMTHFD1LMNASOSTMTHFD2 | |
| Leucovorin SCHEMBL29385578 | 0.93 | DHFR (1.00) | DHFRMTHFD1LMNASOSTMTHFD2 | |
| Leucovorin SCHEMBL36113 | 0.93 | DHFR (1.00) | DHFRMTHFD1LMNASOSTMTHFD2 | |
| Leucovorin SCHEMBL29379632 | 0.93 | DHFR (1.00) | DHFRMTHFD1LMNASOSTMTHFD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2773355-B1 | METHODS, FORMULATIONS, AND KITS FOR RAPIDLY REPLETING FOLATE LEVELS IN WOMEN | SOUTH ALABAMA MEDICAL SCIENCE FOUND (US) | 2022-06-08 | — | — | EP | disclosed |