SCHEMBL1880683

SCHEMBL1880683

CC1Nc2cc(O)c(O)cc2C1C

nearest known ligand 0.43

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
AR P10275 2/20 0.43
NR3C1 P04150 1/20 0.43
PGR P06401 1/20 0.43
NR3C2 P08235 1/20 0.43
MAOA P21397 3/20 0.36
DRD2 P14416 2/20 0.36
KDM4E B2RXH2 1/20 0.36
CYP2C9 P11712 1/20 0.36
TSHR P16473 1/20 0.36
DRD3 P35462 1/20 0.36
HIF1A Q16665 1/20 0.36
HSD17B10 Q99714 1/20 0.36
DRD4 P21917 1/20 0.36
NNMT P40261 1/20 0.34
HTR2C P28335 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7574764 0.76 AR (0.32) ARNR3C1PGRNR3C2MAOA
SCHEMBL22019330 0.68 HTR2C (0.40) ARNR3C1PGRNR3C2KDM4E
SCHEMBL21317798 0.67 HTR2A (0.39) ARNR3C1PGRNR3C2KDM4E
SCHEMBL13894801 0.67 HTR2C (0.41) ARNR3C1PGRNR3C2MAOA
SCHEMBL28818061 0.65 MAOA (0.41) MAOADRD2KDM4ECYP2C9TSHR
SCHEMBL14475657 0.64 KIF11 (0.40) ARNR3C1PGRNR3C2KDM4E
SCHEMBL13831889 0.64 KIF11 (0.40) ARNR3C1PGRNR3C2DRD2
SCHEMBL18324164 0.64 HTR5A (0.41) KDM4E
SCHEMBL172934 0.64 HTR5A (0.41) KDM4E
SCHEMBL18271939 0.64 HTR5A (0.41) KDM4E

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 31 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2623093-B1 DYE FOR KERATIN FIBERS USING BILIRUBIN OXIDASE AND INDOLE DERIVATIVES AMANO ENZYME INC (JP) 2016-05-25 EP claimed
US-20140359950-A1 DYEING OF KERATIN FIBERS USING INDOLE ANALOGUE AMANO ENZYME INC. (JP) 2014-12-11 US claimed
EP-2708223-B1 DYEING AGENT AND USE FOR SAME AMANO ENZYME INC (JP) 2017-02-01 EP disclosed
EP-3067041-A1 METHOD FOR DYEING KERATIN FIBERS, KERATIN FIBER DYE Shisei Chemical Co., Ltd. (JP) 2016-09-14 EP disclosed
US-9358198-B2 Dyeing of keratin fibers using indole analogue AMANO ENZYME INC. (JP) 2016-06-07 US disclosed
EP-2623093-B1 DYE FOR KERATIN FIBERS USING BILIRUBIN OXIDASE AND INDOLE DERIVATIVES AMANO ENZYME INC (JP) 2016-05-25 EP disclosed
US-20140359950-A1 DYEING OF KERATIN FIBERS USING INDOLE ANALOGUE AMANO ENZYME INC. (JP) 2014-12-11 US disclosed
US-8740994-B2 Dyeing agent and use for same AMANO ENZYME INC. (JP) 2014-06-03 US disclosed
EP-2708223-A1 DYEING AGENT AND USE FOR SAME Amano Enzyme Inc. (JP) 2014-03-19 EP disclosed
US-20140068875-A1 DYEING AGENT AND USE FOR SAME AMANO ENZYME INC (JP) 2014-03-13 US disclosed
EP-2623093-A1 DYE FOR KERATIN FIBERS USING INDOLE ANALOGUE Amano Enzyme Inc. (JP) 2013-08-07 EP disclosed
US-6958080-B2 Compositions for dyeing keratinous fiber LION CORPORATION (JP) 2005-10-25 US disclosed
US-20050170485-A1 Culture having phenol oxidase-like activity MANDOM CORPORATION (JP) 2005-08-04 US disclosed
EP-1533371-A1 CULTURE HAVING PHENOL OXIDASE-LIKE ACTIVITY Mandom Corporation (JP) 2005-05-25 EP disclosed
US-20030106166-A1 Compositions for dyeing keratinous fiber LION CORPORATION (JP) 2003-06-12 US disclosed
EP-1234569-A1 COMPOSITIONS FOR DYEING HORNY FIBERS Lion Corporation (JP) 2002-08-28 EP disclosed
EP-1189576-A2 HAIR COMPOSITION COMPRISING AN OXIDASE AND CYCLODEXTRIN Lion Corporation (JP) 2002-03-27 EP disclosed
EP-1142561-A1 HAIR DYE COMPOSITIONS Lion Corporation (JP) 2001-10-10 EP disclosed
EP-1142562-A1 HAIR DYE COMPOSITIONS Lion Corporation (JP) 2001-10-10 EP disclosed
WO-2001000144-A2 HAIR COMPOSITION COMPRISING AN OXIDASE AND CYCLODEXTRIN LION CORPORATION (JP) 2001-01-04 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20030106166-A1 Compositions for dyeing keratinous fiber KRT18, LPO, CKMT1A; CKMT1B AR 3430/4885NR3C1 4758/4885PGR 3639/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.