Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FOLH1 | Q04609 | 2/20 | 0.40 |
| ▸ | ALB | P02768 | 2/20 | 0.39 |
| ▸ | TSHR | P16473 | 2/20 | 0.36 |
| ▸ | ITGB1 | P05556 | 2/20 | 0.36 |
| ▸ | ITGA4 | P13612 | 2/20 | 0.36 |
| ▸ | NOD1 | Q9Y239 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | THRB | P10828 | 1/20 | 0.35 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.35 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.35 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.35 |
| ▸ | THPO | P40225 | 1/20 | 0.35 |
| ▸ | RECQL | P46063 | 1/20 | 0.35 |
| ▸ | BLM | P54132 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | SRC | P12931 | 1/20 | 0.34 |
| ▸ | FNTA | P49354 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23323338 | 0.84 | EPHX2 (0.40) | FOLH1ALBITGB1ITGA4SMN1; SMN2 | |
| SCHEMBL23552243 | 0.84 | EPHX2 (0.40) | FOLH1ALBITGB1ITGA4SMN1; SMN2 | |
| SCHEMBL23566950 | 0.84 | EPHX2 (0.40) | FOLH1ALBITGB1ITGA4SMN1; SMN2 | |
| SCHEMBL23323337 | 0.84 | EPHX2 (0.40) | FOLH1ALBITGB1ITGA4SMN1; SMN2 | |
| SCHEMBL2754993 | 0.77 | LMNA (0.56) | FOLH1ITGB1ITGA4MAPTKDM4E | |
| SCHEMBL25542887 | 0.76 | ALB (0.58) | FOLH1ALBNOD1SMN1; SMN2FNTA | |
| SCHEMBL24378366 | 0.75 | MAPT (0.50) | FOLH1ITGB1ITGA4MAPTKDM4E | |
| SCHEMBL20830620 | 0.74 | ITGB1 (0.40) | TSHRITGB1ITGA4ALDH1A1 | |
| SCHEMBL18811280 | 0.74 | TSHR (0.45) | TSHRKDM4ERECQLSMN1; SMN2ALDH1A1 | |
| SCHEMBL12298114 | 0.74 | ITGB1 (0.50) | FOLH1TSHRITGB1ITGA4MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20170232120-A1 | DENDRIMER COMPOSITIONS AND USE IN TREATMENT OF NEUROLOGICAL AND CNS DISORDERS | Ashvattha Therapeutics, Inc. | 2017-08-17 | — | — | US | disclosed |
| US-20170119897-A1 | DENDRIMER COMPOSITIONS AND USE IN TREATMENT OF NECROTIZING ENTEROCOLITIS AND OTHER GASTROINTESTINAL DISORDERS | THE JOHNS HOPKINS UNIVERSITY | 2017-05-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170232120-A1 | DENDRIMER COMPOSITIONS AND USE IN TREATMENT OF NEUROLOGICAL AND CNS DISORDERS | GRM6, TLR3, TLR6 | FOLH1 1615/4885ALB 1027/4885TSHR 1714/4885 |
| US-20170119897-A1 | DENDRIMER COMPOSITIONS AND USE IN TREATMENT OF NECROTIZING ENTEROCOLITIS AND OTHER GASTROINTESTINAL DISORDERS | PAM, TLR9, TLR3 | FOLH1 1222/4885ALB 114/4885TSHR 3682/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.