Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABL1 | P00519 | 1/20 | 0.46 |
| ▸ | BCR | P11274 | 1/20 | 0.46 |
| ▸ | NPBWR1 | P48145 | 2/20 | 0.36 |
| ▸ | MCHR1 | Q99705 | 2/20 | 0.36 |
| ▸ | PDK2 | Q15119 | 2/20 | 0.36 |
| ▸ | ADORA2B | P29275 | 7/20 | 0.35 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.35 |
| ▸ | ADORA1 | P30542 | 2/20 | 0.35 |
| ▸ | P2RY1 | P47900 | 1/20 | 0.35 |
| ▸ | GRM5 | P41594 | 1/20 | 0.35 |
| ▸ | GRM1 | Q13255 | 1/20 | 0.35 |
| ▸ | SYK | P43405 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | PPARD | Q03181 | 1/20 | 0.33 |
| ▸ | PPARA | Q07869 | 1/20 | 0.33 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.33 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.33 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.33 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.33 |
| ▸ | RXRA | P19793 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16475039 | 0.93 | ABL1 (0.37) | ABL1BCRNPBWR1MCHR1PDK2 | |
| SCHEMBL22421237 | 0.90 | ADORA2B (0.39) | ABL1BCRNPBWR1MCHR1ADORA2B | |
| SCHEMBL16475040 | 0.88 | JAK2 (0.37) | ABL1BCRNPBWR1MCHR1PDK2 | |
| SCHEMBL16474986 | 0.87 | ABL1 (0.41) | ABL1BCRNPBWR1MCHR1GRM5 | |
| SCHEMBL16479499 | 0.87 | ABL1 (0.47) | ABL1BCRNPBWR1MCHR1PDK2 | |
| SCHEMBL17803745 | 0.85 | ADORA2B (0.37) | ABL1BCRNPBWR1MCHR1PDK2 | |
| SCHEMBL18812103 | 0.83 | PRKACA (0.35) | ABL1PDK2MAPK1FGFR1 | |
| SCHEMBL17803742 | 0.82 | ABL1 (0.40) | ABL1BCRNPBWR1MCHR1ADORA2B | |
| SCHEMBL16475038 | 0.82 | GRK2 (0.37) | ABL1BCRNPBWR1MCHR1GRM5 | |
| SCHEMBL16479503 | 0.81 | ABL1 (0.46) | ABL1BCRNPBWR1MCHR1PDK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20170121345-A1 | ANTI-FIBROTIC PYRIDINONES | GENENTECH, INC. | 2017-05-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170121345-A1 | ANTI-FIBROTIC PYRIDINONES | MMP1, COL1A1, COL2A1 | ABL1 3203/4885BCR 4359/4885NPBWR1 3131/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.