Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRKACA | P17612 | 1/20 | 0.35 |
| ▸ | PRKACG | P22612 | 1/20 | 0.35 |
| ▸ | PRKACB | P22694 | 1/20 | 0.35 |
| ▸ | ABL1 | P00519 | 5/20 | 0.33 |
| ▸ | CSF1R | P07333 | 5/20 | 0.33 |
| ▸ | LYN | P07948 | 5/20 | 0.33 |
| ▸ | TGFBR1 | P36897 | 5/20 | 0.33 |
| ▸ | TGFBR2 | P37173 | 5/20 | 0.33 |
| ▸ | SIK1 | P57059 | 5/20 | 0.33 |
| ▸ | SIK2 | Q9H0K1 | 5/20 | 0.33 |
| ▸ | SIK3 | Q9Y2K2 | 5/20 | 0.33 |
| ▸ | PRKAB2 | O43741 | 4/20 | 0.33 |
| ▸ | PRKAG1 | P54619 | 4/20 | 0.33 |
| ▸ | PRKAA1 | Q13131 | 4/20 | 0.33 |
| ▸ | PDE4A | P27815 | 1/20 | 0.33 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.33 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.33 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.33 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.33 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18077761 | 0.90 | AXL (0.36) | PDE4APDE4BPDE4CPDE4DPDK2 | |
| SCHEMBL16475039 | 0.90 | ABL1 (0.37) | ABL1PDE3BPDE3APDK2 | |
| SCHEMBL18812001 | 0.85 | PRKACA (0.35) | PRKACAPRKACGPRKACBABL1CSF1R | |
| SCHEMBL17803975 | 0.85 | GRK2 (0.38) | PDE4APDE4BPDE4CPDE4DMAPT | |
| SCHEMBL22421237 | 0.83 | ADORA2B (0.39) | ABL1RAB9A | |
| SCHEMBL18077729 | 0.83 | BRD4 (0.36) | RAB9AF10 | |
| SCHEMBL18812005 | 0.83 | ABL1 (0.46) | ABL1FGFR1PDK2MAPK1 | |
| SCHEMBL17803745 | 0.82 | ADORA2B (0.37) | ABL1PDE3BPDE3APDK2 | |
| SCHEMBL16474986 | 0.80 | ABL1 (0.41) | ABL1PDE3BPDE3A | |
| SCHEMBL18077656 | 0.79 | PDK2 (0.35) | ABL1LYNFGFR1PDK2BTK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20170121345-A1 | ANTI-FIBROTIC PYRIDINONES | GENENTECH, INC. | 2017-05-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170121345-A1 | ANTI-FIBROTIC PYRIDINONES | MMP1, COL1A1, COL2A1 | PRKACA 3867/4885PRKACG 4019/4885PRKACB 3770/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.