Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOS1 | P29475 | 4/20 | 0.49 |
| ▸ | NOS3 | P29474 | 2/20 | 0.49 |
| ▸ | CCR5 | P51681 | 2/20 | 0.43 |
| ▸ | PLAU | P00749 | 1/20 | 0.41 |
| ▸ | CES2 | O00748 | 1/20 | 0.40 |
| ▸ | GALR3 | O60755 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.40 |
| ▸ | CASP1 | P29466 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | GSTA1 | P08263 | 3/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18817930 | 1.00 | NOS1 (0.49) | NOS1NOS3CCR5PLAUCES2 | |
| SCHEMBL18845626 | 0.82 | MAOA (0.48) | NOS1PLAUCES2GALR3CYP1A2 | |
| SCHEMBL18817925 | 0.81 | LMNA (0.50) | NOS1CCR5PLAUCES2GALR3 | |
| SCHEMBL18817922 | 0.81 | LMNA (0.50) | NOS1CCR5PLAUCES2GALR3 | |
| SCHEMBL18817903 | 0.81 | MAPT (0.47) | NOS1NOS3PLAUCES2GALR3 | |
| SCHEMBL18817901 | 0.81 | MAPT (0.47) | NOS1NOS3PLAUCES2GALR3 | |
| SCHEMBL18817935 | 0.80 | GSTA1 (0.47) | NOS1NOS3PLAUCES2GALR3 | |
| SCHEMBL18817938 | 0.80 | GSTA1 (0.47) | NOS1NOS3PLAUCES2GALR3 | |
| SCHEMBL18817947 | 0.77 | TMPRSS4 (0.46) | NOS1NOS3PLAUCES2GALR3 | |
| SCHEMBL18817944 | 0.77 | TMPRSS4 (0.46) | NOS1NOS3PLAUCES2GALR3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10155753-B2 | 4-substituted-2-(5-substituted-1H-indol-2-yl)phenol derivatives, methods for preparing the phenol derivatives and pharmaceutical compositions for inhibiting cell proliferation and migration including the phenol derivatives | KOREA UNIVERSITY RESEARCH AND BUSINESS FOUNDATION (KR) | 2018-12-18 | — | — | US | disclosed |
| US-20170129879-A1 | 4-SUBSTITUTED-2-(5-SUBSTITUTED-1H-INDOL-2-YL)PHENOL DERIVATIVES, METHODS FOR PREPARING THE PHENOL DERIVATIVES AND PHARMACEUTICAL COMPOSITIONS FOR INHIBITING CELL PROLIFERATION AND MIGRATION INCLUDING THE PHENOL DERIVATIVES | KOREA UNIVERSITY RESEARCH AND BUSINESS FOUNDATION (KR) | 2017-05-11 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10155753-B2 | 4-substituted-2-(5-substituted-1H-indol-2-yl)phenol derivatives, methods for preparing the phenol derivatives and pharmaceutical compositions for inhibiting cell proliferation and migration including the phenol derivatives | MKI67, CCNI, CDK4 | NOS1 811/4885NOS3 198/4885CCR5 217/4885 |
| US-20170129879-A1 | 4-SUBSTITUTED-2-(5-SUBSTITUTED-1H-INDOL-2-YL)PHENOL DERIVATIVES, METHODS FOR PREPARING THE PHENOL DERIVATIVES AND PHARMACEUTICAL COMPOSITIONS FOR INHIBITING CELL PROLIFERATION AND MIGRATION INCLUDING THE PHENOL DERIVATIVES | MKI67, CCNI, CDK4 | NOS1 811/4885NOS3 198/4885CCR5 217/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.