Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSTA1 | P08263 | 3/20 | 0.47 |
| ▸ | CES2 | O00748 | 1/20 | 0.46 |
| ▸ | GALR3 | O60755 | 1/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.46 |
| ▸ | CASP1 | P29466 | 1/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 3/20 | 0.44 |
| ▸ | NPC1 | O15118 | 3/20 | 0.44 |
| ▸ | RAB9A | P51151 | 3/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.44 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | PLAU | P00749 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | GAA | P10253 | 2/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | NOS3 | P29474 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18817935 | 1.00 | GSTA1 (0.47) | GSTA1CES2GALR3CYP1A2CYP2C9 | |
| SCHEMBL18845626 | 0.85 | MAOA (0.48) | GSTA1CES2GALR3CYP1A2CYP2C9 | |
| SCHEMBL18817922 | 0.84 | LMNA (0.50) | GSTA1CES2GALR3CYP1A2CYP2C9 | |
| SCHEMBL18817903 | 0.84 | MAPT (0.47) | GSTA1CES2GALR3CYP1A2CYP2C9 | |
| SCHEMBL18817901 | 0.84 | MAPT (0.47) | GSTA1CES2GALR3CYP1A2CYP2C9 | |
| SCHEMBL18817925 | 0.84 | LMNA (0.50) | GSTA1CES2GALR3CYP1A2CYP2C9 | |
| SCHEMBL18817929 | 0.80 | NOS1 (0.49) | GSTA1CES2GALR3CYP1A2CYP2C9 | |
| SCHEMBL18817947 | 0.80 | TMPRSS4 (0.46) | GSTA1CES2GALR3CYP1A2CYP2C9 | |
| SCHEMBL18817944 | 0.80 | TMPRSS4 (0.46) | GSTA1CES2GALR3CYP1A2CYP2C9 | |
| SCHEMBL18817930 | 0.80 | NOS1 (0.49) | GSTA1CES2GALR3CYP1A2CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10155753-B2 | 4-substituted-2-(5-substituted-1H-indol-2-yl)phenol derivatives, methods for preparing the phenol derivatives and pharmaceutical compositions for inhibiting cell proliferation and migration including the phenol derivatives | KOREA UNIVERSITY RESEARCH AND BUSINESS FOUNDATION (KR) | 2018-12-18 | — | — | US | disclosed |
| US-20170129879-A1 | 4-SUBSTITUTED-2-(5-SUBSTITUTED-1H-INDOL-2-YL)PHENOL DERIVATIVES, METHODS FOR PREPARING THE PHENOL DERIVATIVES AND PHARMACEUTICAL COMPOSITIONS FOR INHIBITING CELL PROLIFERATION AND MIGRATION INCLUDING THE PHENOL DERIVATIVES | KOREA UNIVERSITY RESEARCH AND BUSINESS FOUNDATION (KR) | 2017-05-11 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10155753-B2 | 4-substituted-2-(5-substituted-1H-indol-2-yl)phenol derivatives, methods for preparing the phenol derivatives and pharmaceutical compositions for inhibiting cell proliferation and migration including the phenol derivatives | MKI67, CCNI, CDK4 | GSTA1 4340/4885CES2 1762/4885GALR3 825/4885 |
| US-20170129879-A1 | 4-SUBSTITUTED-2-(5-SUBSTITUTED-1H-INDOL-2-YL)PHENOL DERIVATIVES, METHODS FOR PREPARING THE PHENOL DERIVATIVES AND PHARMACEUTICAL COMPOSITIONS FOR INHIBITING CELL PROLIFERATION AND MIGRATION INCLUDING THE PHENOL DERIVATIVES | MKI67, CCNI, CDK4 | GSTA1 4340/4885CES2 1762/4885GALR3 825/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.