Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LOXL2 | Q9Y4K0 | 4/20 | 0.37 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | VCP | P55072 | 2/20 | 0.35 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.32 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.31 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.31 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.31 |
| ▸ | PARP1 | P09874 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8146071 | 0.87 | LOXL2 (0.35) | LOXL2MAPTKDM4EALDH1A1VCP | |
| SCHEMBL694595 | 0.85 | ADORA1 (0.39) | LOXL2KDM4EALDH1A1VCPMTNR1A | |
| SCHEMBL2562389 | 0.81 | RHEB (0.36) | LOXL2MTNR1AMTNR1B | |
| SCHEMBL5178946 | 0.78 | MTNR1A (0.36) | LOXL2MTNR1AMTNR1B | |
| SCHEMBL188218 | 0.78 | GAA (0.35) | LOXL2MTNR1AMTNR1B | |
| SCHEMBL9074352 | 0.77 | LOXL2 (0.33) | LOXL2 | |
| SCHEMBL704753 | 0.77 | LOXL2 (0.33) | LOXL2 | |
| SCHEMBL1661482 | 0.75 | SIRT1 (0.42) | LOXL2MAPTKDM4EALDH1A1MTNR1A | |
| SCHEMBL5778675 | 0.75 | RHEB (0.37) | LOXL2KDM4EALDH1A1MTNR1AMTNR1B | |
| SCHEMBL6587779 | 0.75 | F2 (0.51) | LOXL2PARP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5550233-A | AUTOIMMUNE DISEASES; PREVENTION OF TRANSPLANT REJECTION | MERCK & CO., INC. (US) | 1996-08-27 | — | — | US | claimed |
| EP-2401281-A1 | PYRIMIDOPYRIMIDOINDAZOLE DERIVATIVE | MSD K.K. (JP) | 2012-01-04 | — | — | EP | disclosed |
| WO-2010098367-A1 | PYRIMIDOPYRIMIDOINDAZOLE DERIVATIVE | BANYU PHARMACEUTICAL CO.,LTD. (JP) | 2010-09-02 | — | — | WO | disclosed |
| EP-1753719-A1 | SUBSTITUTED PYRROLIDINE-2-ONES | Novartis AG (CH) | 2007-02-21 | — | — | EP | disclosed |
| WO-2005118535-A1 | SUBSTITUTED PYRROLIDINE-2-ONES | NOVARTIS AG (CH) | 2005-12-15 | — | — | WO | disclosed |
| US-5550233-A | AUTOIMMUNE DISEASES; PREVENTION OF TRANSPLANT REJECTION | MERCK & CO., INC. (US) | 1996-08-27 | — | — | US | disclosed |