Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | TSHR | P16473 | 2/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 2/20 | 0.39 |
| ▸ | IDO1 | P14902 | 1/20 | 0.38 |
| ▸ | ABCC1 | P33527 | 2/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | EZH2 | Q15910 | 1/20 | 0.36 |
| ▸ | ATM | Q13315 | 1/20 | 0.36 |
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.36 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.36 |
| ▸ | TAS1R2 | Q8TE23 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13279927 | 0.88 | ALDH1A1 (0.47) | LMNATSHRHPGDALDH1A1MAPT | |
| SCHEMBL18829835 | 0.87 | LMNA (0.42) | LMNATSHRHPGDALDH1A1MAPT | |
| SCHEMBL15710904 | 0.84 | ALDH1A1 (0.44) | LMNATSHRHPGDALDH1A1MAPT | |
| SCHEMBL13468019 | 0.82 | LMNA (0.39) | LMNATSHRHPGDALDH1A1MAPT | |
| SCHEMBL17804327 | 0.80 | LMNA (0.40) | LMNATSHRHPGDALDH1A1MAPT | |
| SCHEMBL18829848 | 0.77 | EZH2 (0.54) | LMNAALDH1A1MAPTNPSR1GAA | |
| SCHEMBL18830367 | 0.77 | EZH2 (0.40) | LMNAALDH1A1MAPTNPSR1GAA | |
| SCHEMBL18829845 | 0.75 | ALDH1A1 (0.41) | TSHRHPGDALDH1A1MAPTNPSR1 | |
| SCHEMBL13468049 | 0.75 | EZH2 (0.39) | TSHRHPGDALDH1A1MAPTNPSR1 | |
| SCHEMBL13280243 | 0.75 | ALDH1A1 (0.46) | LMNATSHRHPGDALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3470396-A1 | SUBSTITUTED BENZENE COMPOUNDS | Epizyme, Inc. (US) | 2019-04-17 | — | — | EP | disclosed |
| EP-3165520-A1 | SUBSTITUTED BENZENE COMPOUNDS | Epizyme Inc (US) | 2017-05-10 | — | — | EP | disclosed |