Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | EZH2 | Q15910 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | IDO1 | P14902 | 1/20 | 0.35 |
| ▸ | TCF4 | P15884 | 1/20 | 0.35 |
| ▸ | CTNNB1 | P35222 | 1/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
| ▸ | ABCC1 | P33527 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18830371 | 0.84 | ALDH1A1 (0.36) | LMNAALDH1A1HSD11B1HPGDTSHR | |
| SCHEMBL18829979 | 0.82 | LMNA (0.47) | LMNAALDH1A1HPGDTSHREZH2 | |
| SCHEMBL13279927 | 0.82 | ALDH1A1 (0.47) | LMNAALDH1A1HPGDTSHRNPC1 | |
| SCHEMBL18829835 | 0.81 | LMNA (0.42) | LMNAALDH1A1HPGDTSHREZH2 | |
| SCHEMBL15710904 | 0.78 | ALDH1A1 (0.44) | LMNAALDH1A1HPGDTSHRNPC1 | |
| SCHEMBL17804355 | 0.78 | EZH2 (0.41) | ALDH1A1HPGDTSHREZH2TCF4 | |
| SCHEMBL17804325 | 0.71 | EZH2 (0.42) | LMNAALDH1A1HPGDTSHREZH2 | |
| SCHEMBL5309095 | 0.70 | CTNNB1 (0.46) | ALDH1A1HPGDTSHRTCF4CTNNB1 | |
| SCHEMBL13280243 | 0.70 | ALDH1A1 (0.46) | LMNAALDH1A1HPGDTSHRL3MBTL1 | |
| SCHEMBL17804327 | 0.69 | LMNA (0.40) | LMNAALDH1A1HPGDTSHRNPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3165520-A1 | SUBSTITUTED BENZENE COMPOUNDS | Epizyme Inc (US) | 2017-05-10 | — | — | EP | disclosed |
| WO-2012142513-A1 | SUBSTITUTED BENZENE COMPOUNDS | Epizyme, Inc. (US) | 2012-10-18 | — | — | WO | disclosed |