Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EZH2 | Q15910 | 7/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | IDO1 | P14902 | 4/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | SLC6A9 | P48067 | 1/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18830366 | 0.83 | EZH2 (0.39) | EZH2ALDH1A1MAPTNPSR1LMNA | |
| SCHEMBL18829848 | 0.83 | EZH2 (0.54) | EZH2ALDH1A1MAPTNPSR1LMNA | |
| SCHEMBL18829845 | 0.82 | ALDH1A1 (0.41) | EZH2ALDH1A1MAPTNPSR1IDO1 | |
| SCHEMBL13468049 | 0.81 | EZH2 (0.39) | EZH2ALDH1A1MAPTNPSR1GAA | |
| SCHEMBL18829979 | 0.77 | LMNA (0.47) | EZH2ALDH1A1MAPTNPSR1LMNA | |
| SCHEMBL18830419 | 0.76 | EZH2 (0.36) | EZH2ALDH1A1MAPTNPSR1 | |
| SCHEMBL18829987 | 0.73 | EZH2 (0.57) | EZH2 | |
| SCHEMBL13280323 | 0.72 | RXRA (0.39) | EZH2ALDH1A1MAPTNPSR1IDO1 | |
| SCHEMBL13280553 | 0.71 | EZH2 (0.54) | EZH2ALDH1A1MAPTNPSR1IDO1 | |
| SCHEMBL18829901 | 0.71 | EZH2 (0.57) | EZH2LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3470396-A1 | SUBSTITUTED BENZENE COMPOUNDS | Epizyme, Inc. (US) | 2019-04-17 | — | — | EP | disclosed |
| EP-3165520-A1 | SUBSTITUTED BENZENE COMPOUNDS | Epizyme Inc (US) | 2017-05-10 | — | — | EP | disclosed |