Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EZH2 | Q15910 | 8/20 | 0.39 |
| ▸ | RAB9A | P51151 | 2/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | GPR35 | Q9HC97 | 3/20 | 0.34 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.34 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.33 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13280323 | 0.89 | RXRA (0.39) | EZH2RAB9APOLBALDH1A1MAPT | |
| SCHEMBL15709875 | 0.86 | CFTR (0.40) | EZH2RAB9APOLBALDH1A1GPR35 | |
| SCHEMBL18830367 | 0.83 | EZH2 (0.40) | EZH2ALDH1A1MAPTNPSR1LMNA | |
| SCHEMBL18829848 | 0.81 | EZH2 (0.54) | EZH2ALDH1A1MAPTNPSR1LMNA | |
| SCHEMBL18829845 | 0.80 | ALDH1A1 (0.41) | EZH2RAB9AALDH1A1MAPTNPSR1 | |
| SCHEMBL13468049 | 0.79 | EZH2 (0.39) | EZH2RAB9AALDH1A1MAPTNPSR1 | |
| SCHEMBL18829979 | 0.74 | LMNA (0.47) | EZH2ALDH1A1MAPTNPSR1LMNA | |
| SCHEMBL18830419 | 0.74 | EZH2 (0.36) | EZH2RAB9AALDH1A1MAPTNPSR1 | |
| SCHEMBL13280553 | 0.69 | EZH2 (0.54) | EZH2ALDH1A1MAPTNPSR1GAA | |
| SCHEMBL18830127 | 0.69 | EZH2 (0.49) | EZH2RAB9APOLBALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3470396-A1 | SUBSTITUTED BENZENE COMPOUNDS | Epizyme, Inc. (US) | 2019-04-17 | — | — | EP | disclosed |
| EP-3165520-A1 | SUBSTITUTED BENZENE COMPOUNDS | Epizyme Inc (US) | 2017-05-10 | — | — | EP | disclosed |