Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 3/20 | 0.46 |
| ▸ | POLB | P06746 | 3/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.46 |
| ▸ | BLM | P54132 | 2/20 | 0.46 |
| ▸ | RECQL | P46063 | 2/20 | 0.46 |
| ▸ | MAPT | P10636 | 2/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.46 |
| ▸ | PARP1 | P09874 | 1/20 | 0.46 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | F2 | P00734 | 2/20 | 0.41 |
| ▸ | F10 | P00742 | 1/20 | 0.41 |
| ▸ | F12 | P00748 | 1/20 | 0.41 |
| ▸ | F7 | P08709 | 1/20 | 0.41 |
| ▸ | F3 | P13726 | 1/20 | 0.41 |
| ▸ | PKM | P14618 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL229639 | 0.74 | LMNA (0.58) | TSHRPOLBMAPTHSD17B10TDP1 | |
| SCHEMBL6545293 | 0.73 | CES1 (0.39) | TSHRPOLBCYP2C19BLMRECQL | |
| SCHEMBL1542178 | 0.73 | F2 (0.39) | TSHRPOLBCYP2C19BLMRECQL | |
| SCHEMBL5592713 | 0.71 | CES2 (0.54) | TSHRMAPTF2LMNACES1 | |
| SCHEMBL8745554 | 0.69 | TDP1 (0.52) | TSHRPOLBCYP2C19BLMRECQL | |
| SCHEMBL5171285 | 0.69 | TDP1 (0.52) | TSHRPOLBCYP2C19BLMRECQL | |
| Benzamide SCHEMBL7094288 | 0.69 | PARP1 (0.84) | TSHRPOLBCYP2C19BLMRECQL | |
| SCHEMBL27814828 | 0.68 | TSHR (0.46) | TSHRPOLBCYP2C19BLMRECQL | |
| SCHEMBL27340280 | 0.67 | TSHR (0.50) | TSHRPOLBCYP2C19BLMRECQL | |
| Benzamide SCHEMBL28067624 | 0.65 | PARP1 (0.76) | TSHRPOLBCYP2C19BLMRECQL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9650414-B1 | Dual-action EP4 agonist—bisphosphonate conjugates and uses thereof | SIMON FRASER UNIVERSITY (CA) | 2017-05-16 | — | — | US | disclosed |