Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA3 | P0DMS8 | 3/20 | 0.39 |
| ▸ | TRPC4 | Q9UBN4 | 2/20 | 0.38 |
| ▸ | TRPC5 | Q9UL62 | 2/20 | 0.38 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.38 |
| ▸ | TRPC1 | P48995 | 1/20 | 0.37 |
| ▸ | PDE5A | O76074 | 4/20 | 0.35 |
| ▸ | PPARG | P37231 | 4/20 | 0.35 |
| ▸ | PPARA | Q07869 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19375568 | 0.93 | TRPC4 (0.43) | TRPC4TRPC5KCNH2TRPC1P2RX3 | |
| SCHEMBL18835341 | 0.86 | TRPC4 (0.41) | ADORA3TRPC4TRPC5KCNH2TRPC1 | |
| SCHEMBL21499680 | 0.85 | P2RX3 (0.39) | ADORA3TRPC4TRPC5KCNH2TRPC1 | |
| SCHEMBL19505572 | 0.85 | TRPC4 (0.47) | ADORA3TRPC4TRPC5KCNH2TRPC1 | |
| SCHEMBL18834916 | 0.83 | TRPC4 (0.45) | TRPC4TRPC5KCNH2TRPC1P2RX3 | |
| SCHEMBL20432022 | 0.83 | TRPC4 (0.42) | TRPC4TRPC5KCNH2TRPC1P2RX3 | |
| SCHEMBL19375181 | 0.83 | TRPC5 (0.41) | ADORA3TRPC4TRPC5KCNH2TRPC1 | |
| SCHEMBL18834483 | 0.83 | TRPC4 (0.39) | ADORA3TRPC4TRPC5KCNH2TRPC1 | |
| SCHEMBL22619613 | 0.82 | TRPC5 (0.57) | TRPC4TRPC5KCNH2TRPC1ALDH1A1 | |
| SCHEMBL18833918 | 0.82 | P2RX3 (0.35) | ADORA3TRPC4TRPC5KCNH2TRPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2970303-B3 | SUBSTITUTED XANTHINES AND METHODS OF USE THEREOF | HYDRA BIOSCIENCES INC (US) | 2018-08-01 | — | — | EP | disclosed |
| EP-2970303-B9 | SUBSTITUTED XANTHINES AND METHODS OF USE THEREOF | HYDRA BIOSCIENCES INC (US) | 2017-09-20 | — | — | EP | disclosed |
| EP-2970303-B1 | SUBSTITUTED XANTHINES AND METHODS OF USE THEREOF | HYDRA BIOSCIENCES INC (US) | 2017-05-10 | — | — | EP | disclosed |