Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPC5 | Q9UL62 | 3/20 | 0.41 |
| ▸ | TRPC4 | Q9UBN4 | 2/20 | 0.41 |
| ▸ | TRPC1 | P48995 | 1/20 | 0.41 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.41 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.35 |
| ▸ | P2RX3 | P56373 | 5/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 4/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.34 |
| ▸ | USP2 | O75604 | 2/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.34 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.34 |
| ▸ | PCSK9 | Q8NBP7 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 2/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | NPBWR1 | P48145 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18835341 | 0.93 | TRPC4 (0.41) | TRPC5TRPC4TRPC1KCNH2ADORA3 | |
| SCHEMBL19374906 | 0.93 | TRPC5 (0.49) | TRPC5TRPC4TRPC1KCNH2ADORA3 | |
| SCHEMBL21499680 | 0.90 | P2RX3 (0.39) | TRPC5TRPC4TRPC1KCNH2ADORA3 | |
| SCHEMBL19375398 | 0.88 | P2RX3 (0.38) | TRPC5TRPC4TRPC1KCNH2ADORA3 | |
| SCHEMBL19375436 | 0.86 | P2RX7 (0.35) | TRPC5TRPC4TRPC1KCNH2ADORA3 | |
| SCHEMBL20432022 | 0.86 | TRPC4 (0.42) | TRPC5TRPC4TRPC1KCNH2P2RX3 | |
| SCHEMBL20432442 | 0.85 | TRPC5 (0.48) | TRPC5TRPC4TRPC1KCNH2ADORA3 | |
| SCHEMBL20432432 | 0.85 | PDE5A (0.37) | TRPC5ADORA3P2RX3TSHRALDH1A1 | |
| SCHEMBL22619613 | 0.85 | TRPC5 (0.57) | TRPC5TRPC4TRPC1KCNH2P2RX3 | |
| SCHEMBL19505500 | 0.84 | TRPC5 (0.50) | TRPC5TRPC4TRPC1KCNH2ADORA3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2970303-B9 | SUBSTITUTED XANTHINES AND METHODS OF USE THEREOF | HYDRA BIOSCIENCES INC (US) | 2017-09-20 | — | — | EP | disclosed |