SCHEMBL1884392

SCHEMBL1884392

Cc1cc(C(C)(C)C)cc(C(C)(C)C)c1-c1c(-c2c(C)cc(C(C)(C)C)cc2C(C)(C)C)c(-c2c(C)cc(C(C)(C)C)cc2C(C)(C)C)c2c(c1-c1c(C)cc(C(C)(C)C)cc1C(C)(C)C)=c1ccccc1=2

nearest known ligand 0.35

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
TSHR P16473 2/20 0.35
CYP1A2 P05177 1/20 0.35
CYP3A4 P08684 1/20 0.35
CYP2C9 P11712 1/20 0.35
CYP2C19 P33261 1/20 0.35
POLB P06746 1/20 0.34
GABRA1 P14867 1/20 0.32
GABRB2 P47870 1/20 0.32
MEN1 O00255 1/20 0.31
NPC1 O15118 1/20 0.31
KMT2A Q03164 1/20 0.31
HTR1D P28221 1/20 0.31
ALDH1A1 P00352 1/20 0.31
TDP1 Q9NUW8 1/20 0.31
HSP90AA1 P07900 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL673853 0.91 TSHR (0.37) TSHRCYP1A2CYP3A4CYP2C9CYP2C19
SCHEMBL1893783 0.81 CYP1A2 (0.38) TSHRCYP1A2CYP3A4CYP2C9CYP2C19
SCHEMBL27845904 0.81 RARA (0.33) TSHRCYP1A2CYP3A4CYP2C9CYP2C19
SCHEMBL1883326 0.80 ALDH1A1 (0.42) TSHRCYP2C9CYP2C19POLBGABRA1
SCHEMBL28015827 0.75 NPC1 (0.35) TSHRCYP1A2CYP3A4CYP2C9CYP2C19
SCHEMBL28227436 0.74 TSHR (0.38) TSHRCYP1A2CYP3A4CYP2C9CYP2C19
SCHEMBL499729 0.74 CA2 (0.43) TSHRGABRA1GABRB2ALDH1A1TDP1
SCHEMBL1889673 0.73 ALDH1A1 (0.33) TSHRGABRA1GABRB2ALDH1A1TDP1
SCHEMBL1882864 0.72 NPC1 (0.36) POLBMEN1NPC1KMT2AHTR1D
SCHEMBL1881869 0.72 GABRA1 (0.32) TSHRGABRA1GABRB2ALDH1A1TDP1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7947342-B2 Polarizer protective film, manufacturing method thereof, polarizing plate and liquid crystal display KONICA MINOLTA OPTO, INC. (JP) 2011-05-24 US disclosed
US-20100104879-A1 CLEAR HARD COAT FILM, ANTI-REFLECTION FILM, POLARIZING PLATE AND DISPLAY DEVICE EMPLOYING THE SAME KONICA MINOLTA OPTO, INC. (JP) 2010-04-29 US disclosed
EP-2012150-A1 POLARIZING PLATE PROTECTION FILM, METHOD FOR PRODUCING THE SAME, POLARIZING PLATE AND LIQUID CRYSTAL DISPLAY Konica Minolta Opto, Inc. (JP) 2009-01-07 EP disclosed
US-20070254115-A1 Polarizer protective film, manufacturing method thereof, polarizing plate and liquid crystal display KONICA MINOLTA OPTO, INC. (JP) 2007-11-01 US disclosed