Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 5/20 | 0.74 |
| ▸ | MEN1 | O00255 | 4/20 | 0.74 |
| ▸ | MAPT | P10636 | 4/20 | 0.69 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.69 |
| ▸ | HPGD | P15428 | 3/20 | 0.69 |
| ▸ | LMNA | P02545 | 1/20 | 0.69 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.69 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.61 |
| ▸ | NPC1 | O15118 | 6/20 | 0.60 |
| ▸ | RAB9A | P51151 | 6/20 | 0.60 |
| ▸ | TP53 | P04637 | 4/20 | 0.60 |
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.57 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.57 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.57 |
| ▸ | TSHR | P16473 | 1/20 | 0.57 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.57 |
| ▸ | GAA | P10253 | 1/20 | 0.55 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.51 |
| ▸ | POLB | P06746 | 1/20 | 0.50 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13210583 | 0.76 | ALDH1A1 (0.79) | KMT2AMEN1ALDH1A1HPGDLMNA | |
| SCHEMBL5974770 | 0.74 | KMT2A (0.73) | KMT2AMEN1ALDH1A1HPGDLMNA | |
| SCHEMBL13210704 | 0.74 | KMT2A (0.81) | KMT2AMEN1ALDH1A1HPGDLMNA | |
| SCHEMBL1898147 | 0.74 | LMNA (0.55) | KMT2AMEN1LMNAKDM4ENPSR1 | |
| SCHEMBL13464290 | 0.73 | MEN1 (0.52) | KMT2AMEN1MAPTALDH1A1HPGD | |
| SCHEMBL13281290 | 0.73 | MEN1 (0.52) | KMT2AMEN1MAPTALDH1A1HPGD | |
| SCHEMBL7500312 | 0.73 | KMT2A (0.84) | KMT2AMEN1MAPTALDH1A1HPGD | |
| SCHEMBL6450945 | 0.73 | KMT2A (0.84) | KMT2AMEN1ALDH1A1HPGDLMNA | |
| SCHEMBL5906560 | 0.73 | BRAF (0.54) | KMT2AMEN1MAPTALDH1A1HPGD | |
| SCHEMBL20102643 | 0.72 | NPC1 (0.59) | KMT2AMEN1MAPTALDH1A1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20250057813-A1 | APOPTOSIS RELATED PROTEIN IN THE TGF-BETA SIGNALING PATHWAY (ARTS) MIMETIC COMPOUNDS, COMPOSITIONS, METHODS AND USES THEREOF IN INDUCTION OF APOPTOSIS | CARMEL-HAIFA UNIVERSITY ECONOMIC CORPORATION LTD. (IL) | 2025-02-20 | — | — | US | disclosed |
| WO-2023175615-A1 | ARTS MIMETIC COMPONDS AND COMBINATIONS THEREOF FOR TREATING HIGH-RISK NEUROBLASTOMA | CARMEL-HAIFA UNIVERSITY ECONOMIC CORPORATION LTD. (IL) | 2023-09-21 | — | — | WO | disclosed |
| WO-2023166507-A1 | APOPTOSIS RELATED PROTEIN IN THE TGF-BETA SIGNALING PATHWAY (ARTS) AND ARTS MIMETIC SMALL MOLECULE COMPOUNDS FOR UPREGULATING P53 LEVEL | CARMEL-HAIFA UNIVERSITY ECONOMIC CORPORATION LTD. (IL) | 2023-09-07 | — | — | WO | disclosed |
| WO-2023161940-A1 | APOPTOSIS RELATED PROTEIN IN THE TGF-BETA SIGNALING PATHWAY (ARTS) MIMETIC COMPOUNDS, COMPOSITIONS, METHODS AND USES THEREOF IN INDUCTION OF APOPTOSIS | CARMEL-HAIFA UNIVERSITY ECONOMIC CORPORATION LTD. (IL) | 2023-08-31 | — | — | WO | disclosed |
| WO-2017077535-A1 | APOPTOSIS RELATED PROTEIN IN THE TGF-BETA SIGNALING PATHWAY (ARTS) MIMETIC COMPOUNDS, COMPOSITIONS, METHODS AND USES THEREOF IN INDUCTION OF DIFFERENTIATION AND/OR APOPTOSIS OF PREMALIGNANT AND MALIGNANT CELLS, THEREBY RESTORING THEIR NORMAL-LIKE PHENOTYPE | CARMEL-HAIFA UNIVERSITY ECONOMIC CORPORATION LTD. (IL) | 2017-05-11 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20250057813-A1 | APOPTOSIS RELATED PROTEIN IN THE TGF-BETA SIGNALING PATHWAY (ARTS) MIMETIC COMPOUNDS, COMPOSITIONS, METHODS AND USES THEREOF IN INDUCTION OF APOPTOSIS | BID, BIRC5, BAD | KMT2A 3400/4885MEN1 3316/4885MAPT 2985/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.