Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4A | O75164 | 1/20 | 0.41 |
| ▸ | KDM4B | O94953 | 1/20 | 0.41 |
| ▸ | KDM5C | P41229 | 1/20 | 0.41 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.41 |
| ▸ | PDCD1 | Q15116 | 1/20 | 0.40 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.40 |
| ▸ | SIRT2 | Q8IXJ6 | 4/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | PRMT6 | Q96LA8 | 2/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | NOS1 | P29475 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | S1PR3 | Q99500 | 1/20 | 0.35 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.35 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18860206 | 0.74 | CHRM2 (0.42) | KDM4AKDM4BKDM5CKDM5BPDCD1 | |
| SCHEMBL16006938 | 0.73 | SIGMAR1 (0.54) | KDM5BSIRT2KDM4EMEN1ALDH1A1 | |
| SCHEMBL18831147 | 0.72 | MC4R (0.44) | SIRT2KDM4EPRMT6CHRM2EPHX2 | |
| SCHEMBL14076165 | 0.68 | PRMT6 (0.42) | PDCD1CD274KDM4ECYP3A4MAPT | |
| SCHEMBL18880300 | 0.67 | CHRM2 (0.42) | KDM4AKDM5CKDM5BSIRT2KDM4E | |
| SCHEMBL23891936 | 0.66 | CYP1A2 (0.44) | KDM4ECYP3A4MAPTPOLBPRMT6 | |
| SCHEMBL12213655 | 0.66 | PRMT6 (0.46) | PDCD1CD274KDM4ECYP3A4MAPT | |
| SCHEMBL18880283 | 0.65 | PRMT6 (0.42) | KDM4ECYP3A4MAPTPRMT6LMNA | |
| SCHEMBL15217666 | 0.65 | KDM4E (0.48) | KDM4AKDM5CPDCD1CD274KDM4E | |
| SCHEMBL27726968 | 0.65 | CHRM2 (0.62) | SIRT2KDM4ELMNAMEN1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2961736-B1 | INHIBITORS OF HISTONE DEMETHYLASES | GILEAD SCIENCES INC (US) | 2018-04-11 | — | — | EP | disclosed |
| EP-3170811-A1 | ETHYL PYRIDINE-4-CARBOXYLATE COMPOUND AS INHIBITOR OF HISTONE DEMETHYLASES | Gilead Sciences, Inc. (US) | 2017-05-24 | — | — | EP | disclosed |