Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRMT6 | Q96LA8 | 3/20 | 0.42 |
| ▸ | LOXL2 | Q9Y4K0 | 8/20 | 0.42 |
| ▸ | LOX | P28300 | 3/20 | 0.42 |
| ▸ | LOXL3 | P58215 | 1/20 | 0.41 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.40 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.39 |
| ▸ | NOS1 | P29475 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | NOS3 | P29474 | 1/20 | 0.37 |
| ▸ | NOS2 | P35228 | 1/20 | 0.37 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23891936 | 0.82 | CYP1A2 (0.44) | PRMT6LOXL2EPHX2ADRB2NOS1 | |
| SCHEMBL27113641 | 0.81 | LOXL2 (0.40) | LOXL2LOXLOXL3ADRB2NOS1 | |
| SCHEMBL14076165 | 0.81 | PRMT6 (0.42) | PRMT6LOXL2EPHX2ADRB2NOS1 | |
| SCHEMBL4107151 | 0.79 | LOXL2 (0.61) | LOXL2LOXLOXL3ADRB2NOS1 | |
| SCHEMBL18831147 | 0.79 | MC4R (0.44) | PRMT6EPHX2KDM4EHRH3ALOX15 | |
| SCHEMBL10061634 | 0.78 | NOS1 (0.62) | PRMT6EPHX2ADRB2NOS1KDM4E | |
| SCHEMBL12213655 | 0.78 | PRMT6 (0.46) | PRMT6LOXL2EPHX2ADRB2NOS1 | |
| SCHEMBL15200880 | 0.78 | NOS3 (0.61) | LOXL2LOXLOXL3NOS1KDM4E | |
| Hydrochloric Acid SCHEMBL5013442 | 0.77 | LOXL2 (0.59) | LOXL2LOXLOXL3ADRB2NOS1 | |
| SCHEMBL27115679 | 0.76 | LOXL2 (0.36) | LOXL2LOXLOXL3NOS1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3170811-A1 | ETHYL PYRIDINE-4-CARBOXYLATE COMPOUND AS INHIBITOR OF HISTONE DEMETHYLASES | Gilead Sciences, Inc. (US) | 2017-05-24 | — | — | EP | disclosed |