Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MC4R | P32245 | 2/20 | 0.44 |
| ▸ | MC5R | P33032 | 2/20 | 0.44 |
| ▸ | MC3R | P41968 | 1/20 | 0.44 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.41 |
| ▸ | SIRT2 | Q8IXJ6 | 4/20 | 0.38 |
| ▸ | FERMT2 | Q96AC1 | 1/20 | 0.36 |
| ▸ | SCN8A | Q9UQD0 | 1/20 | 0.36 |
| ▸ | PRMT6 | Q96LA8 | 2/20 | 0.36 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.36 |
| ▸ | ROCK1 | Q13464 | 2/20 | 0.34 |
| ▸ | MAOB | P27338 | 1/20 | 0.34 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.34 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | EP300 | Q09472 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18860206 | 0.88 | CHRM2 (0.42) | CHRM2SIRT2SCN8APRMT6HRH3 | |
| SCHEMBL10483857 | 0.81 | CHRM2 (0.42) | MC4RMC5RMC3RCHRM2SIRT2 | |
| SCHEMBL19147944 | 0.80 | SIGMAR1 (0.39) | MC4RMC5RMC3RCHRM2SIRT2 | |
| SCHEMBL18880300 | 0.79 | CHRM2 (0.42) | CHRM2SIRT2KDM4E | |
| SCHEMBL18880283 | 0.79 | PRMT6 (0.42) | PRMT6HRH3EPHX2ALOX15KDM4E | |
| SCHEMBL10483909 | 0.78 | MC4R (0.50) | MC4RMC5RMC3RCHRM2SCN8A | |
| SCHEMBL23428545 | 0.77 | CHRM2 (0.45) | CHRM2SIRT2FERMT2SCN8AMAOB | |
| SCHEMBL16006938 | 0.75 | SIGMAR1 (0.54) | SIRT2KDM4E | |
| SCHEMBL10483900 | 0.75 | LOXL2 (0.56) | MC4RMC5RMC3RCHRM2SCN8A | |
| SCHEMBL10483879 | 0.75 | LOX (0.56) | MC4RMC5RMC3RCHRM2FERMT2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9650339-B2 | Inhibitors of histone demethylases | GILEAD SCIENCES, INC. (US) | 2017-05-16 | — | — | US | claimed |