Known targets — ChEMBL curated mechanism
AGTR1DHFRGABBR1GABBR2GABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGARTNR3C2PBP2XPTGS1PTGS2VKORC1blablaT-3blaT-4blaT-5blaT-6dacAdacBdacCfolAftsImrcAmrcBmrdApbp1apbp1bpbp2apbp2bpbp3polthyA
The experimentally established mechanism targets of Potassium Ion. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IDE | P14735 | 1/20 | 0.57 |
| ▸ | MAPT | P10636 | 9/20 | 0.51 |
| ▸ | MEN1 | O00255 | 7/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 7/20 | 0.51 |
| ▸ | MYC | P01106 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.42 |
| ▸ | GAA | P10253 | 2/20 | 0.42 |
| ▸ | NPC1 | O15118 | 3/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 4/20 | 0.41 |
| ▸ | RAB9A | P51151 | 3/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.41 |
| ▸ | HSP90AA1 | P07900 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Potassium Ion SCHEMBL18862927 | 1.00 | IDE (0.57) | IDEMAPTMEN1KMT2AMYC | |
| SCHEMBL18862937 | 0.96 | IDE (0.57) | IDEMAPTMEN1KMT2AMYC | |
| Lithium Ion SCHEMBL30623415 | 0.96 | IDE (0.57) | IDEMAPTMEN1KMT2AMYC | |
| SCHEMBL18862936 | 0.96 | IDE (0.57) | IDEMAPTMEN1KMT2AMYC | |
| Methyl Red SCHEMBL36580593 | 0.82 | MYC (0.74) | IDEMAPTMEN1KMT2AMYC | |
| SCHEMBL30884072 | 0.82 | IDE (0.79) | IDEMAPTMEN1KMT2AMYC | |
| SCHEMBL2481541 | 0.82 | IDE (0.79) | IDEMAPTMEN1KMT2AMYC | |
| SCHEMBL169230 | 0.82 | IDE (0.79) | IDEMAPTMEN1KMT2AMYC | |
| SCHEMBL28903951 | 0.82 | IDE (0.79) | IDEMAPTMEN1KMT2AMYC | |
| SCHEMBL10652915 | 0.81 | IDE (0.61) | IDEMAPTMEN1KMT2AMYC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-108350487-B | Compounds and systems for improved signal detection | 加利福尼亚太平洋生物科学股份有限公司 | 2022-05-27 | — | — | CN | disclosed |
| US-10995365-B2 | Compounds and systems for improving signal detection | PACIFIC BIOSCIENCES OF CALIFORNIA, INC. | 2021-05-04 | — | — | US | disclosed |
| EP-3350350-B1 | COMPOUNDS AND SYSTEMS FOR IMPROVING SIGNAL DETECTION | PACIFIC BIOSCIENCES CALIFORNIA INC (US) | 2021-04-14 | — | — | EP | disclosed |
| US-10435741-B2 | Compounds and systems for improving signal detection | PACIFIC BIOSCIENCES OF CALIFORNIA, INC. (US) | 2019-10-08 | — | — | US | disclosed |
| US-20190106742-A1 | COMPOUNDS AND SYSTEMS FOR IMPROVING SIGNAL DETECTION | PACIFIC BIOSCIENCES CALIFORNIA INC (US) | 2019-04-11 | — | — | US | disclosed |
| EP-3350350-A1 | COMPOUNDS AND SYSTEMS FOR IMPROVING SIGNAL DETECTION | Pacific Biosciences of California, Inc. (US) | 2018-07-25 | — | — | EP | disclosed |
| US-20170145494-A1 | COMPOUNDS AND SYSTEMS FOR IMPROVING SIGNAL DETECTION | PACIFIC BIOSCIENCES OF CALIFORNIA, INC. | 2017-05-25 | — | — | US | disclosed |