Benzoic Acid

Benzoic Acid

SCHEMBL1886522

CCNC.O=C(O)c1ccccc1

nearest known ligand 0.64

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

CACNA1CCACNA1DCACNA1FCACNA1SDPP4HTR1BHTR1D

The experimentally established mechanism targets of Benzoic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TSHR P16473 3/20 0.64
DAO P14920 1/20 0.64
NAPRT Q6XQN6 1/20 0.64
CES1 P23141 4/20 0.54
CES2 O00748 3/20 0.54
SRD5A2 P31213 2/20 0.54
ALDH1A1 P00352 3/20 0.50
MEN1 O00255 2/20 0.50
KMT2A Q03164 2/20 0.50
SMN1; SMN2 Q16637 2/20 0.50
GAA P10253 1/20 0.50
KDM4E B2RXH2 1/20 0.50
CYP3A4 P08684 1/20 0.50
MAPT P10636 1/20 0.50
HPGD P15428 1/20 0.50
ALOX15 P16050 1/20 0.50
MAPK1 P28482 1/20 0.50
TDP1 Q9NUW8 1/20 0.50
TP53 P04637 1/20 0.48
CYP2C8 P10632 1/20 0.47

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Isophthalic Acid SCHEMBL27573445 0.87 CA12 (0.52) ALDH1A1MEN1KMT2AGAAKDM4E
Benzophenone SCHEMBL28239206 0.86 ALDH1A1 (0.64) CES1SRD5A2ALDH1A1MEN1KMT2A
Benzophenone SCHEMBL28002310 0.86 ALDH1A1 (0.64) CES1SRD5A2ALDH1A1MEN1KMT2A
Benzoic Acid SCHEMBL64441 0.86 TSHR (0.64) TSHRDAONAPRTCES1CES2
Benzoic Acid SCHEMBL28601772 0.85 TSHR (0.78) TSHRDAONAPRTCES1CES2
Benzoic Acid SCHEMBL2400344 0.85 TSHR (0.78) TSHRDAONAPRTCES1CES2
Benzoic Acid SCHEMBL28693411 0.85 TSHR (0.78) TSHRDAONAPRTCES1CES2
Benzoic Acid SCHEMBL65296 0.85 TSHR (0.78) TSHRDAONAPRTCES1CES2
Benzoic Acid SCHEMBL9705228 0.85 TSHR (0.78) TSHRDAONAPRTCES1CES2
Benzoic Acid SCHEMBL2330040 0.83 TSHR (0.74) TSHRDAONAPRTCES1CES2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 20 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4314302-A1 TETRACYCLINE-INDUCIBLE EXPRESSION SYSTEMS DNA TWOPOINTO INC. (US) 2024-02-07 EP disclosed
US-20230323396-A1 TETRACYCLINE-INDUCIBLE EXPRESSION SYSTEM DNA TWOPOINTO INC. (US) 2023-10-12 US disclosed
US-11566262-B2 Tetracycline-inducible expression systems DNA TWOPOINTO INC. (US) 2023-01-31 US disclosed
CN-109012750-A A kind of cuprous oxide catalysis system and its preparation method and application suitable for water phase click reaction 河南师范大学 2018-12-18 CN disclosed
EP-1797186-B1 EXPRESSION SYSTEM, COMPONENTS THEREOF AND METHODS OF USE NAT RES COUNCIL CANADA (CA) 2016-05-25 EP disclosed
US-8728759-B2 Reverse cumate repressor mutant NATIONAL RESEARCH COUNCIL OF CANADA (CA) 2014-05-20 US disclosed
US-8252556-B2 Reverse cumate repressor mutant NATIONAL RESEARCH COUNCIL OF CANADA (CA) 2012-08-28 US disclosed
US-8163894-B2 DNA for eukaryotic expression of CymR NATIONAL RESEARCH COUNCIL OF CANADA (CA) 2012-04-24 US disclosed
US-20110171686-A1 REVERSE CUMATE REPRESSOR MUTANT NATIONAL RESEARCH COUNCIL OF CANADA (CA) 2011-07-14 US disclosed
US-7935788-B2 Reverse cumate repressor mutant NATIONAL RESEARCH COUNCIL OF CANADA (CA) 2011-05-03 US disclosed
US-20100210830-A1 SYSTEM FOR INDUCIBLE EXPRESSION IN EUKARYOTIC CELLS NATIONAL RESEARCH COUNCIL OF CANADA (CA) 2010-08-19 US disclosed
US-7745592-B2 Cumate-inducible expression system for eukaryotic cells NATIONAL RESEARCH COUNCIL OF CANADA (CA) 2010-06-29 US disclosed
US-20090176275-A1 EXPRESSION SYSTEM, COMPONENTS THEREOF AND METHODS OF USE NATIONAL RESEARCH COUNCIL OF CANADA (CA) 2009-07-09 US disclosed
US-20080311618-A1 Expression System, Components Thereof and Methods of Use NATIONAL RESEARCH COUNCIL OF CANADA (CA) 2008-12-18 US disclosed
EP-1797186-A4 EXPRESSION SYSTEM, COMPONENTS THEREOF AND METHODS OF USE CA NAT RESEARCH COUNCIL (CA) 2008-11-12 EP disclosed
EP-1797186-A1 EXPRESSION SYSTEM, COMPONENTS THEREOF AND METHODS OF USE NATIONAL RESEARCH COUNCIL OF CANADA (CA) 2007-06-20 EP disclosed
WO-2006037215-A1 EXPRESSION SYSTEM, COMPONENTS THEREOF AND METHODS OF USE NATIONAL RESEARCH COUNCIL OF CANADA (CA) 2006-04-13 WO disclosed
US-20040205834-A1 System for inducible expression in eukaryotic cells NATIONAL RESEARCH COUNCIL OF CANADA (CA) 2004-10-14 US disclosed
EP-1385946-A2 A SYSTEM FOR INDUCIBLE EXPRESSION IN EUKARYOTIC CELLS NATIONAL RESEARCH COUNCIL OF CANADA (CA) 2004-02-04 EP disclosed
WO-2002088346-A2 A SYSTEM FOR INDUCIBLE EXPRESSION IN EUKARYOTIC CELLS NATIONAL RESEARCH COUNCIL OF CANADA (CA) 2002-11-07 WO disclosed