SCHEMBL188660

SCHEMBL188660

Brc1cncc(OCc2ccccc2)c1

nearest known ligand 0.62

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
MAOB P27338 8/20 0.62
ALOX5 P09917 1/20 0.47
LMNA P02545 1/20 0.46
CYP1A2 P05177 1/20 0.46
PTGS1 P23219 1/20 0.46
SLC6A2 P23975 1/20 0.46
CYP2C19 P33261 1/20 0.46
PTGS2 P35354 1/20 0.46
SLC6A3 Q01959 1/20 0.46
HIF1A Q16665 1/20 0.46
HDAC6 Q9UBN7 1/20 0.46
PDGFRB P09619 1/20 0.46
PDGFRA P16234 1/20 0.46
GAA P10253 1/20 0.44
MAPT P10636 1/20 0.44
MAOA P21397 1/20 0.44
RAB9A P51151 1/20 0.44
SMN1; SMN2 Q16637 1/20 0.44
L3MBTL1 Q9Y468 1/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7450860 0.92 MAOB (0.54) MAOBALOX5LMNACYP1A2PTGS1
SCHEMBL24619909 0.87 LTA4H (0.51) MAOBRAB9A
SCHEMBL8512404 0.87 MAOB (0.56) MAOBALOX5LMNACYP1A2PTGS1
SCHEMBL9369289 0.84 RAB9A (0.49) MAOBALOX5RAB9A
SCHEMBL21675841 0.83 MAOB (0.62) MAOBMAOARAB9A
SCHEMBL6119008 0.83 MAOB (0.68) MAOBMAOA
SCHEMBL189829 0.82 MAOB (0.53) MAOBRAB9ASMN1; SMN2
SCHEMBL1773163 0.82 MAOB (0.49) MAOBMAOA
SCHEMBL24628664 0.81 APP (0.45) MAOBLMNAMAPTRAB9A
SCHEMBL6582384 0.81 CYP1A2 (0.56) MAOBALOX5LMNACYP1A2PTGS1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 522 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-115943145-B Pyrazolopyrimidine compounds as ATR kinase inhibitors BEIJING TIDE PHARMACEUTICAL CO.,LTD. (CN) 2026-05-26 CN disclosed
US-12595263-B2 Pyrazolopyrimidine compound used as ATR kinase inhibitor BEIJING TIDE PHARMACEUTICAL CO., LTD. (CN) 2026-04-07 US disclosed
US-20260015323-A1 PIPERIDINE COMPOUNDS TELO THERAPEUTICS INC (US) 2026-01-15 US disclosed
EP-4143179-B1 AZETIDIN-3-YLMETHANOL DERIVATIVES AS CCR6 RECEPTOR MODULATORS FOR THE TREATMENT OF CANCER IDORSIA PHARMACEUTICALS LTD (CH) 2025-10-22 EP disclosed
US-12378216-B2 Heteroaryl(heterocyclyl)methanol compounds useful in the treatment of hyperglycaemia ATROGI AB (SE) 2025-08-05 US disclosed
EP-4587435-A1 MODIFIED PROTEINS AND PROTEIN BINDERS AND DEGRADERS Cullgen (Shanghai), Inc. (CN) 2025-07-23 EP disclosed
US-12338253-B2 Nitrogen-containing polycyclic fused ring compound, pharmaceutical composition thereof, preparation method therefor and use thereof APPLIED PHARMACEUTICAL SCIENCE, INC. (CN) 2025-06-24 US disclosed
US-20240398770-A1 HETEROARYL SUBSTITUTED BETA-HYDROXYETHYLAMINES FOR USE IN TREATING HYPERGLYCAEMIA ATROGI AB (SE) 2024-12-05 US disclosed
US-12036210-B2 Heteroaryl substituted beta-hydroxyethylamines for use in treating hyperglycaemia ATROGI AB (SE) 2024-07-16 US disclosed
US-12036210-B2 Heteroaryl substituted beta-hydroxyethylamines for use in treating hyperglycaemia ATROGI AB (SE) 2024-07-16 US disclosed
US-5134148-A Heterocycles for use as inhibitors of leukotrienes IMPERIAL CHEMICAL INDUSTRIES PLC (GB) 1992-07-28 US disclosed
US-5132328-A Lipoxygenase inhibitors as antiinflammatory agents or antiallergens IMPERIAL CHEMICAL INDUSTRIES PLC (GB) 1992-07-21 US disclosed
US-5098930-A Inhibitors of lipoxygenase for treatment of diseases mediated with leukotrienes IMPERIAL CHEMICAL INDUSTRIES PLC (GB) 1992-03-24 US disclosed
US-5089495-A Lipoxygenase inhibitors IMPERIAL CHEMICAL INDUSTRIES PLC (FR) 1992-02-18 US disclosed
CN-1046903-A Process for preparing heterocyclic ether derivatives ICI PLC (GB) 1990-11-14 CN disclosed
EP-0385662-A2 Heterocycles with inhibitory activity of 5-lipoxygenase ZENECA LIMITED (GB) 1990-09-05 EP disclosed
EP-0385680-A2 Heterocyclic ethers as 5-lipoxygenase inhibitors ZENECA LIMITED (GB) 1990-09-05 EP disclosed
EP-0381375-A1 Heterocyclic derivatives IMPERIAL CHEMICAL INDUSTRIES PLC (GB) 1990-08-08 EP disclosed
EP-0375368-A2 Alcohol and ether derivatives ZENECA LIMITED (GB) 1990-06-27 EP disclosed
EP-0375404-A2 Heterocyclic derivatives IMPERIAL CHEMICAL INDUSTRIES PLC (GB) 1990-06-27 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-12338253-B2 Nitrogen-containing polycyclic fused ring compound, pharmaceutical composition thereof, preparation method therefor and use thereof RET, WEE1, TIAM1 MAOB 2907/4885ALOX5 3080/4885LMNA 2939/4885
US-20260015323-A1 PIPERIDINE COMPOUNDS XPO1, NR0B1, NR2E1 MAOB 1974/4885ALOX5 3315/4885LMNA 1245/4885
US-20240398770-A1 HETEROARYL SUBSTITUTED BETA-HYDROXYETHYLAMINES FOR USE IN TREATING HYPERGLYCAEMIA SLC5A2, SLC5A1, GPR119 MAOB 903/4885ALOX5 3690/4885LMNA 2140/4885
US-12378216-B2 Heteroaryl(heterocyclyl)methanol compounds useful in the treatment of hyperglycaemia SLC5A1, GPR119, SLC5A2 MAOB 1865/4885ALOX5 2545/4885LMNA 1919/4885
US-12036210-B2 Heteroaryl substituted beta-hydroxyethylamines for use in treating hyperglycaemia SLC5A2, SLC5A1, GPR119 MAOB 739/4885ALOX5 3461/4885LMNA 2131/4885
US-12595263-B2 Pyrazolopyrimidine compound used as ATR kinase inhibitor ATR, CHEK1, ATRIP MAOB 2919/4885ALOX5 4493/4885LMNA 2258/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.