SCHEMBL188680

SCHEMBL188680

c1csc(-c2ccn[nH]2)c1

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
POLB P06746 1/20 1.00
GAA P10253 1/20 0.53
GFER P55789 1/20 0.53
SCN4A P35499 1/20 0.47
PDPK1 O15530 1/20 0.47
CCNB2 O95067 1/20 0.46
CDK1 P06493 1/20 0.46
CCNB1 P14635 1/20 0.46
GSK3B P49841 1/20 0.46
CDK5 Q00535 1/20 0.46
CDK5R1 Q15078 1/20 0.46
CCNB3 Q8WWL7 1/20 0.46
MEN1 O00255 3/20 0.45
KMT2A Q03164 3/20 0.45
KDM4E B2RXH2 2/20 0.45
ALDH1A1 P00352 2/20 0.45
NPC1 O15118 1/20 0.45
HPGDS O60760 1/20 0.45
LMNA P02545 1/20 0.45
NFKB1 P19838 1/20 0.45

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL298591 0.75 KDM4E (0.64) POLBGAAKDM4EALDH1A1NPC1
SCHEMBL3068150 0.71 SCN4A (0.62) POLBSCN4APDPK1ALDH1A1NPC1
SCHEMBL15088445 0.71 KMT2A (0.57) POLBGAAGFERCCNB2CDK1
SCHEMBL4024470 0.70 GAA (0.57) POLBGAAGFERCCNB2CDK1
SCHEMBL5020250 0.69 POLB (0.53) POLBGAAGFERCCNB2CDK1
SCHEMBL27889994 0.69 POLB (0.53) POLBSCN4APDPK1KDM4EALDH1A1
SCHEMBL12727897 0.69 GAA (0.55) POLBGAAGFERCCNB2CDK1
SCHEMBL1578223 0.68 POLB (0.52) POLBGAAGFERCCNB2CDK1
SCHEMBL1665919 0.68 ADORA3 (0.62) POLBGAAPDPK1CCNB2CDK1
SCHEMBL3545 0.68 L3MBTL1 (0.57) POLBGAAMEN1KMT2AKDM4E

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 51 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20210253871-A1 CORROSION-RESISTANT CONDUCTIVE STRUCTURE AND CORROSION-RESISTANT COATING COMPOSITION TPK UNIVERSAL SOLUTIONS LIMITED (HK) 2021-08-19 US claimed
CN-111192857-A Corrosion-resistant conductive structure and corrosion-resistant coating composition 宸盛光电有限公司 2020-05-22 CN claimed
EP-2699579-A1 PYRAZOLO [4, 3-D]PYRIMIDINES USEFUL AS KINASE INHIBITORS Origenis GmbH (DE) 2014-02-26 EP claimed
WO-2012143144-A1 PYRAZOLO [4, 3-D] PYRIMIDINES USEFUL AS KINASE INHIBITORS ORIGENIS GMBH (DE) 2012-10-26 WO claimed
US-20260103470-A1 ANDROGEN RECEPTOR REGULATION BY SMALL MOLECULE ENANTIOMERS UNIV SOUTHERN CALIFORNIA (US) 2026-04-16 US disclosed
US-12552806-B2 Androgen receptor regulation by small molecule enantiomers UNIVERSITY OF SOUTHERN CALIFORNIA (US) 2026-02-17 US disclosed
US-20240208985-A2 ANDROGEN RECEPTOR REGULATION BY SMALL MOLECULE ENANTIOMERS UNIVERSITY OF SOUTHERN CALIFORNIA (US) 2024-06-27 US disclosed
US-20230133119-A1 ANDROGEN RECEPTOR REGULATION BY SMALL MOLECULE ENANTIOMERS UNIVERSITY OF SOUTHERN CALIFORNIA (US) 2023-05-04 US disclosed
CN-111172542-B Silver thin film etching solution composition, etching method and metal pattern forming method 东友精细化工有限公司 2023-04-11 CN disclosed
EP-4121044-A1 ANDROGEN RECEPTOR REGULATION BY SMALL MOLECULE ENANTIOMERS UNIVERSITY OF SOUTHERN CALIFORNIA (US) 2023-01-25 EP disclosed
WO-2021189051-A1 ANDROGEN RECEPTOR REGULATION BY SMALL MOLECULE ENANTIOMERS UNIVERSITY OF SOUTHERN CALIFORNIA (US) 2021-09-23 WO disclosed
US-20210253871-A1 CORROSION-RESISTANT CONDUCTIVE STRUCTURE AND CORROSION-RESISTANT COATING COMPOSITION TPK UNIVERSAL SOLUTIONS LIMITED (HK) 2021-08-19 US disclosed
US-20090018308-A1 Curable Composition MITSUBISHI GAS CHEMICAL COMPANY, INC. (JP) 2009-01-15 US disclosed
US-7470722-B2 Multicyclic sulfonamide compounds as inhibitors of histone deacetylase for the treatment of disease KALYPSYS, INC. (US) 2008-12-30 US disclosed
US-7470722-B2 Multicyclic sulfonamide compounds as inhibitors of histone deacetylase for the treatment of disease KALYPSYS, INC. (US) 2008-12-30 US disclosed
CN-101175792-A curable composition MITSUBISHI GAS CHEMICAL CO (JP) 2008-05-07 CN disclosed
WO-2008021389-A2 USING PI3K AND MEK MODULATORS IN TREATMENTS OF CANCER EXELIXIS, INC. (US) 2008-02-21 WO disclosed
EP-1882713-A1 CURABLE COMPOSITION MITSUBISHI GAS CHEMICAL COMPANY, INC. (JP) 2008-01-30 EP disclosed
WO-2005123089-A2 MULTICYCLIC SULFONAMIDE COMPOUNDS AS INHIBITORS OF HISTONE DEACETYLASE FOR THE TREATMENT OF DISEASE KALYPSYS, INC. (US) 2005-12-29 WO disclosed
WO-2005077915-A1 PYRIDAZINONES AS ANTAGONISTS OF A4 INTEGRINS JANSSEN PHARMACEUTICA, N.V. (BE) 2005-08-25 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20240208985-A2 ANDROGEN RECEPTOR REGULATION BY SMALL MOLECULE ENANTIOMERS AR, SHBG, NR5A1 POLB 2782/4885GAA 4664/4885GFER 3547/4885
US-20260103470-A1 ANDROGEN RECEPTOR REGULATION BY SMALL MOLECULE ENANTIOMERS AR, FSHR, GNRHR POLB 3048/4885GAA 4809/4885GFER 3223/4885
US-20230133119-A1 ANDROGEN RECEPTOR REGULATION BY SMALL MOLECULE ENANTIOMERS AR, SHBG, NR5A1 POLB 2737/4885GAA 4658/4885GFER 3462/4885
US-12552806-B2 Androgen receptor regulation by small molecule enantiomers AR, ADRA1D, ADRA1A POLB 2614/4885GAA 4621/4885GFER 2444/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.