Folic Acid

Folic Acid

SCHEMBL1887022

Nc1nc(O)c2nc(CNc3ccc(C(=O)N[C@@H](CCC(=O)O)C(=O)O)cc3)cnc2n1.[CaH2]

nearest known ligand 0.73

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KDM4E B2RXH2 2/20 0.72
MEN1 O00255 2/20 0.72
ALDH1A1 P00352 2/20 0.72
TYMS P04818 2/20 0.72
POLB P06746 2/20 0.72
HPGD P15428 2/20 0.72
KMT2A Q03164 2/20 0.72
HSD17B10 Q99714 2/20 0.72
TDP1 Q9NUW8 2/20 0.72
GAA P10253 1/20 0.72
AKR1B1 P15121 1/20 0.72
TSHR P16473 1/20 0.72
PTGS2 P35354 1/20 0.72
DHFR P00374 9/20 0.66
TLR4 O00206 1/20 0.60
LMNA P02545 1/20 0.60
TP53 P04637 1/20 0.60
GLA P06280 1/20 0.60
HMGB1 P09429 1/20 0.60
MAPT P10636 1/20 0.60

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Folic Acid SCHEMBL28298890 1.00 KDM4E (0.72) KDM4EMEN1ALDH1A1TYMSPOLB
Folic Acid SCHEMBL12148554 0.99 KDM4E (0.73) KDM4EMEN1ALDH1A1TYMSPOLB
Folic Acid SCHEMBL3878 0.99 KDM4E (0.73) KDM4EMEN1ALDH1A1TYMSPOLB
Folic Acid SCHEMBL6470174 0.99 KDM4E (0.73) KDM4EMEN1ALDH1A1TYMSPOLB
Folic Acid SCHEMBL29677832 0.99 KDM4E (0.73) KDM4EMEN1ALDH1A1TYMSPOLB
Folic Acid SCHEMBL23388805 0.98 KDM4E (0.72) KDM4EMEN1ALDH1A1TYMSPOLB
Folic Acid SCHEMBL12497751 0.98 KDM4E (0.72) KDM4EMEN1ALDH1A1TYMSPOLB
Folic Acid SCHEMBL652283 0.98 KDM4E (0.72) KDM4EMEN1ALDH1A1TYMSPOLB
Folic Acid SCHEMBL22441084 0.98 KDM4E (0.72) KDM4EMEN1ALDH1A1TYMSPOLB
Folic Acid SCHEMBL19837676 0.98 KDM4E (0.72) KDM4EMEN1ALDH1A1TYMSPOLB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 64 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-119497716-A Crystal form of ENPP1 inhibitor 石药集团中奇制药技术(石家庄)有限公司 2025-02-21 CN claimed
CN-112999122-B Anti-wrinkle moisturizing eye cream and preparation method thereof 江西建昌帮食疗科技有限公司 2023-04-28 CN claimed
CN-110317388-A A kind of packaging material and its preparation method and application directly contacted with drug 奥星衡迅生命科技(上海)有限公司 2019-10-11 CN claimed
CN-110122809-A A kind of diabetes nutritive yam reinforcing powder 熊吉素 2019-08-16 CN claimed
CN-109731075-A Grow Chinese medicine composition, cell nutritious element and the application method of pancreas nourishing the liver control sugar therapy 赵浩淋 2019-05-10 CN claimed
US-12414977-B2 Method of administering seaberry and saw palmetto extracts to inhibit 5α-reductase activity ORYZA OIL & FAT CHEMICAL CO., LTD. (JP) 2025-09-16 US disclosed
US-20250268972-A1 5a-REDUCTASE INHIBITOR ORYZA OIL & FAT CHEMICAL CO., LTD. (JP) 2025-08-28 US disclosed
CN-222677899-U Calcium folate solvent compounding device 连云港金康和信药业有限公司 2025-03-28 CN disclosed
CN-222677899-U Calcium folate solvent compounding device 连云港金康和信药业有限公司 2025-03-28 CN disclosed
CN-118742325-A Methods for preventing or treating diseases or conditions associated with antineoplastic agents 上海岸阔医药科技有限公司 2024-10-01 CN disclosed
CN-118715226-A Compounds and uses thereof 上海岸阔医药科技有限公司 2024-09-27 CN disclosed
CN-115322966-B Batch preparation method of calcium folate nanoparticles and method for inducing differentiation of neural stem cells into cholinergic neurons 山东大学 2024-04-16 CN disclosed
CN-102958540-A Substituted 2,3-dihydroimidazo[1,2-c]quinazoline-containing combinations Bayer Pharma AG 2013-03-06 CN disclosed
US-8017162-B2 Anti-inflammatory agent ORYZA OIL & FAT CHEMICAL CO., LTD. (JP) 2011-09-13 US disclosed
US-7947662-B2 Folates, compositions and uses thereof GNOSIS S.P.A. (IT) 2011-05-24 US disclosed
CN-101970439-A Folate, composition and use thereof GNOSIS SPA 2011-02-09 CN disclosed
EP-2245032-A1 FOLATES, COMPOSITIONS AND USES THEREOF Gnosis S.p.A. (IT) 2010-11-03 EP disclosed
WO-2009103334-A1 FOLATES, COMPOSITIONS AND USES THEREOF GNOSIS S.P.A. (IT) 2009-08-27 WO disclosed
US-20090209543-A1 FOLATES, COMPOSITIONS AND USES THEREOF GNOSIS S.P.A. (IT) 2009-08-20 US disclosed
US-20070154575-A1 Anti-inflammatory agent ORYZA OIL & FAT CHEMICAL CO., LTD. (JP) 2007-07-05 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20070154575-A1 Anti-inflammatory agent TNF, IL18, CD14 KDM4E 2835/4885MEN1 3040/4885ALDH1A1 349/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.