Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | ADRA1A | P35348 | 3/20 | 0.33 |
| ▸ | ADRA2A | P08913 | 3/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.33 |
| ▸ | CA1 | P00915 | 1/20 | 0.33 |
| ▸ | CA2 | P00918 | 1/20 | 0.33 |
| ▸ | CA7 | P43166 | 1/20 | 0.33 |
| ▸ | CA9 | Q16790 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | BLM | P54132 | 1/20 | 0.33 |
| ▸ | AOC3 | Q16853 | 1/20 | 0.31 |
| ▸ | PARP1 | P09874 | 1/20 | 0.31 |
| ▸ | PDE7A | Q13946 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.31 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.31 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17014327 | 0.81 | ADRA1A (0.41) | LMNAADRA1AADRA2APARP1PDE7A | |
| SCHEMBL17014455 | 0.78 | ADRA1A (0.41) | ADRA1AADRA2APARP1ALDH1A1PDE4A | |
| SCHEMBL17014347 | 0.76 | LMNA (0.37) | MEN1KMT2ALMNAL3MBTL1ADRA1A | |
| SCHEMBL17014346 | 0.74 | LMNA (0.43) | MEN1KMT2ALMNAL3MBTL1ADRA1A | |
| SCHEMBL17014463 | 0.72 | ADRA1A (0.45) | ADRA1AADRA2ACA1CA2PARP1 | |
| SCHEMBL17014374 | 0.70 | ADRA2A (0.36) | ADRA1AADRA2AALDH1A1PDE4A | |
| SCHEMBL5722922 | 0.69 | PDE4D (0.45) | MEN1KMT2ALMNAL3MBTL1CA1 | |
| SCHEMBL17014343 | 0.67 | HTR5A (0.47) | MEN1KMT2AADRA2ACA1CA2 | |
| SCHEMBL29862053 | 0.66 | HTR5A (0.46) | ADRA2AALDH1A1 | |
| SCHEMBL17014372 | 0.66 | ALDH1A1 (0.48) | ADRA2AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2900656-B1 | SPIRO RING COMPOUNDS AS HEPATITIS C VIRUS (HCV) INHIBITORS | SUNSHINE LAKE PHARMA CO LTD (CN) | 2017-05-17 | — | — | EP | disclosed |