Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | NPC1 | O15118 | 1/20 | 0.31 |
| ▸ | HTT | P42858 | 1/20 | 0.31 |
| ▸ | RAB9A | P51151 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17014360 | 0.87 | CASP3 (0.38) | NPC1HTTRAB9ASMN1; SMN2L3MBTL1 | |
| SCHEMBL15746315 | 0.71 | CASP3 (0.39) | NPC1HTTRAB9ASMN1; SMN2L3MBTL1 | |
| SCHEMBL18071525 | 0.70 | RAB9A (0.34) | KDM4ENPC1HTTRAB9ASMN1; SMN2 | |
| SCHEMBL17014306 | 0.67 | CASP3 (0.41) | NPC1HTTRAB9ASMN1; SMN2L3MBTL1 | |
| SCHEMBL15692818 | 0.66 | ALDH1A1 (0.32) | NPC1HTTRAB9ASMN1; SMN2 | |
| SCHEMBL15692943 | 0.66 | ALDH1A1 (0.32) | HTTSMN1; SMN2 | |
| SCHEMBL16577469 | 0.65 | CASP3 (0.42) | NPC1HTTRAB9ASMN1; SMN2L3MBTL1 | |
| SCHEMBL17082802 | 0.64 | HTR2C (0.31) | — | |
| SCHEMBL18071562 | 0.64 | DRD2 (0.34) | KDM4E | |
| SCHEMBL7432130 | 0.63 | ALDH1A1 (0.52) | NPC1HTTRAB9AL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2900656-B1 | SPIRO RING COMPOUNDS AS HEPATITIS C VIRUS (HCV) INHIBITORS | SUNSHINE LAKE PHARMA CO LTD (CN) | 2017-05-17 | — | — | EP | disclosed |