SCHEMBL1887392

SCHEMBL1887392

NCCCC1=CC(=O)NC1=O

nearest known ligand 0.32

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
HRH4 Q9H3N8 1/20 0.31
HRH3 Q9Y5N1 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL31652590 0.94 MAOA (0.33) HRH4HRH3
SCHEMBL15228417 0.92 HRH1 (0.34) HRH4HRH3
SCHEMBL4174560 0.92 HRH1 (0.34) HRH4HRH3
Hydrochloric Acid SCHEMBL28319672 0.90 HRH1 (0.33) HRH4HRH3
SCHEMBL1044610 0.87
SCHEMBL5703319 0.87 STAT3 (0.31)
SCHEMBL548121 0.87 STAT3 (0.35)
SCHEMBL10626678 0.86 GSK3A (0.37) HRH4HRH3
Trifluoroacetic Acid SCHEMBL28288442 0.85 HRH4 (0.47) HRH4HRH3
Hydrochloric Acid SCHEMBL15994560 0.85

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 47 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20250215041-A1 System and Method for Aqueous Conjugation of Substrates Using Diels-Alder Chemistry Life Technologies Corporation 2025-07-03 US disclosed
US-20250215045-A1 SYSTEM AND METHOD FOR AQUEOUS CONJUGATION OF SUBSTRATES Life Technologies Corporation 2025-07-03 US disclosed
US-11926854-B2 Soluble intein fusion proteins and methods for purifying biomolecules MERCK PATENT GMBH (DE) 2024-03-12 US disclosed
US-20220267750-A1 Soluble Intein Fusion Proteins And Methods For Purifying Biomolecules MERCK PATENT GMBH (DE) 2022-08-25 US disclosed
US-11326154-B2 Soluble intein fusion proteins and methods for purifying biomolecules MERCK PATENT GMBH (DE) 2022-05-10 US disclosed
US-10723731-B2 Heterobifunctional linkers with polyethylene glycol segments and immune response modifier conjugates made therefrom 3M INNOVATIVE PROPERTIES COMPANY (US) 2020-07-28 US disclosed
US-10442930-B2 Biocompatible N, N-disubstituted sulfonamide-containing fluorescent dye labels VISEN MEDICAL, INC. (US) 2019-10-15 US disclosed
EP-1934202-B1 NICOTINIC ACID AND PICOLINIC ACID DERIVED NEAR-INFRARED FLUOROPHORES VISEN MEDICAL INC (US) 2019-01-09 EP disclosed
US-20180186792-A1 HETEROBIFUNCTIONAL LINKERS WITH POLYETHYLENE GLYCOL SEGMENTS AND IMMUNE RESPONSE MODIFIER CONJUGATES MADE THEREFROM 3M INNOVATIVE PROPERTIES COMPANY 2018-07-05 US disclosed
US-9902724-B2 Heterobifunctional linkers with polyethylene glycol segments and immune response modifier conjugates made therefrom 3M INNOVATIVE PROPERTIES COMPANY (US) 2018-02-27 US disclosed
EP-1934211-A1 BIOCOMPATIBLE N, N-DISUBSTITUTED SULFONAMIDE-CONTAINING FLUORESCENT DYE LABELS Visen Medical, Inc. (US) 2008-06-25 EP disclosed
EP-1934202-A2 NICOTINIC ACID AND PICOLINIC ACID DERIVED NEAR-INFRARED FLUOROPHORES Visen Medical, Inc. (US) 2008-06-25 EP disclosed
CN-1307263-C Fluorescent dye, method and kit for saturation labeling of proteins AMOSEN BIOLOG SCIENCE BRITISH (GB) 2007-03-28 CN disclosed
WO-2007028037-A1 BIOCOMPATIBLE N, N-DISUBSTITUTED SULFONAMIDE-CONTAINING FLUORESCENT DYE LABELS VISEN MEDICAL, INC. (US) 2007-03-08 WO disclosed
WO-2007028163-A1 BIOCOMPATIBLE FLUORESCENT IMAGING AGENTS VISEN MEDICAL, INC. (US) 2007-03-08 WO disclosed
WO-2007028118-A2 NICOTINIC ACID AND PICOLINIC ACID DERIVED NEAR-INFRARED FLUOROPHORES VISEN MEDICAL, INC. (US) 2007-03-08 WO disclosed
US-20050233462-A1 Reagents and a method for saturation labelling of proteins GLOBAL LIFE SCIENCES SOLUTIONS GERMANY GMBH (DE) 2005-10-20 US disclosed
CN-1650168-A Reagents and methods for saturation labelling of proteins AMOSEN BIOLOG SCIENCE BRITISH (GB) 2005-08-03 CN disclosed
EP-1520176-A1 REAGENTS AND A METHOD FOR SATURATION LABELLING OF PROTEINS Amersham Biosciences UK Limited (GB) 2005-04-06 EP disclosed
WO-2004005933-A1 REAGENTS AND A METHOD FOR SATURATION LABELLING OF PROTEINS AMERSHAM BIOSCIENCES UK LIMITED (GB) 2004-01-15 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-10723731-B2 Heterobifunctional linkers with polyethylene glycol segments and immune response modifier conjugates made therefrom IL2, ICOS, CD40 HRH4 381/4885HRH3 463/4885
US-20050233462-A1 Reagents and a method for saturation labelling of proteins SET, IK, MRPS22 HRH4 303/4885HRH3 237/4885
US-20250215041-A1 System and Method for Aqueous Conjugation of Substrates Using Diels-Alder Chemistry AS3MT, DNMT1, RNGTT HRH4 1786/4885HRH3 2563/4885
US-20250215045-A1 SYSTEM AND METHOD FOR AQUEOUS CONJUGATION OF SUBSTRATES RNGTT, HNMT, FPGS HRH4 600/4885HRH3 335/4885
US-20180186792-A1 HETEROBIFUNCTIONAL LINKERS WITH POLYETHYLENE GLYCOL SEGMENTS AND IMMUNE RESPONSE MODIFIER CONJUGATES MADE THEREFROM IL2, ICOS, CD40 HRH4 381/4885HRH3 463/4885
US-10442930-B2 Biocompatible N, N-disubstituted sulfonamide-containing fluorescent dye labels DNPEP, FUT5, NES HRH4 2265/4885HRH3 1806/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.