Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CD274 | Q9NZQ7 | 2/20 | 0.59 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.59 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.59 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.59 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.59 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.59 |
| ▸ | GLA | P06280 | 1/20 | 0.56 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.56 |
| ▸ | POLB | P06746 | 1/20 | 0.55 |
| ▸ | HPGD | P15428 | 2/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.51 |
| ▸ | MEN1 | O00255 | 1/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.51 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.50 |
| ▸ | HRH3 | Q9Y5N1 | 4/20 | 0.49 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.49 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.49 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.49 |
| ▸ | DRD2 | P14416 | 1/20 | 0.48 |
| ▸ | DRD4 | P21917 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22837224 | 0.95 | CD274 (0.62) | CD274ALDH1A1NPSR1CYP1A2CYP2D6 | |
| SCHEMBL3408343 | 0.89 | ALDH1A1 (0.71) | CD274ALDH1A1NPSR1CYP1A2CYP2D6 | |
| SCHEMBL3401326 | 0.88 | CYP1A2 (0.74) | CD274ALDH1A1NPSR1CYP1A2CYP2D6 | |
| SCHEMBL3642214 | 0.82 | CYP1A2 (0.65) | CD274ALDH1A1NPSR1CYP1A2CYP2D6 | |
| SCHEMBL18874371 | 0.80 | LMNA (0.49) | CD274ALDH1A1CYP1A2POLBHPGD | |
| SCHEMBL19877141 | 0.79 | CYP1A2 (0.68) | CD274ALDH1A1NPSR1CYP1A2CYP2D6 | |
| SCHEMBL30969330 | 0.78 | ALDH1A1 (0.71) | CD274ALDH1A1NPSR1CYP1A2CYP2D6 | |
| SCHEMBL9199198 | 0.78 | LMNA (0.67) | CD274ALDH1A1NPSR1CYP1A2CYP2D6 | |
| SCHEMBL3543817 | 0.78 | CD274 (0.92) | CD274ALDH1A1CYP1A2CYP2D6POLB | |
| SCHEMBL29605727 | 0.77 | CYP1A2 (0.74) | ALDH1A1NPSR1CYP1A2CYP2D6CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20210078957-A1 | SUBSTITUTED PYRIMIDINES FOR TREATING BACTERIAL INFECTIONS | FORGE THERAPEUTICS, INC. | 2021-03-18 | — | — | US | disclosed |
| US-10875832-B2 | Substituted pyrimidines for treating bacterial infections | FORGE THERAPEUTICS, INC. (US) | 2020-12-29 | — | — | US | disclosed |
| US-10414735-B2 | Substituted hydroxypyrimidinones for treating bacterial infections | FORGE THERAPEUTICS, INC. (US) | 2019-09-17 | — | — | US | disclosed |
| WO-2017083431-A2 | HYDROXYPYRIDINONE AND HYDROXYPYRIMIDINONE BASED COMPOUNDS FOR TREATING BACTERIAL INFECTIONS | FORGE THERAPEUTICS, INC. (US) | 2017-05-18 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210078957-A1 | SUBSTITUTED PYRIMIDINES FOR TREATING BACTERIAL INFECTIONS | DPYD, TYMP, UMPS | CD274 2990/4885ALDH1A1 1644/4885NPSR1 3809/4885 |
| US-10414735-B2 | Substituted hydroxypyrimidinones for treating bacterial infections | ALPI, HPGDS, SDHB | CD274 3847/4885ALDH1A1 706/4885NPSR1 1427/4885 |
| US-10875832-B2 | Substituted pyrimidines for treating bacterial infections | UMPS, DPYD, TYMP | CD274 4359/4885ALDH1A1 1265/4885NPSR1 3608/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.