SCHEMBL18874243

SCHEMBL18874243

CC(=O)OC1=C(c2c(C)cc(-c3ccccc3)cc2C)C(=O)[C@H]2C3CCC(O3)[C@@H]12

nearest known ligand 0.35

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
L3MBTL1 Q9Y468 1/20 0.35
MAPT P10636 3/20 0.34
KDM4E B2RXH2 2/20 0.34
CNR1 P21554 2/20 0.33
CNR2 P34972 2/20 0.33
ALDH1A1 P00352 2/20 0.32
LMNA P02545 2/20 0.32
ALOX5 P09917 1/20 0.32
BACE1 P56817 1/20 0.32
ADORA3 P0DMS8 3/20 0.32
ADORA2A P29274 2/20 0.32
ADORA1 P30542 2/20 0.32
OXTR P30559 1/20 0.31
AVPR1A P37288 1/20 0.31
MEN1 O00255 1/20 0.31
NPC1 O15118 1/20 0.31
GLA P06280 1/20 0.31
RAB9A P51151 1/20 0.31
KMT2A Q03164 1/20 0.31
MAOA P21397 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6727555 1.00 L3MBTL1 (0.35) L3MBTL1MAPTKDM4ECNR1CNR2
SCHEMBL6727746 0.89 L3MBTL1 (0.33) L3MBTL1MAPTCNR1CNR2ALDH1A1
SCHEMBL9110635 0.89 L3MBTL1 (0.33) L3MBTL1MAPTCNR1CNR2ALDH1A1
SCHEMBL18873885 0.89 L3MBTL1 (0.33) L3MBTL1MAPTKDM4ECNR1CNR2
SCHEMBL18873778 0.89 L3MBTL1 (0.33) L3MBTL1MAPTCNR1CNR2ALDH1A1
SCHEMBL6727443 0.89 L3MBTL1 (0.33) L3MBTL1MAPTKDM4ECNR1CNR2
SCHEMBL6727428 0.83 ALDH1A1 (0.35) L3MBTL1ALDH1A1LMNAMEN1KMT2A
SCHEMBL6727345 0.82 L3MBTL1 (0.39) L3MBTL1MAPTCNR1CNR2ALDH1A1
SCHEMBL18874119 0.82 L3MBTL1 (0.39) L3MBTL1MAPTCNR1CNR2ALDH1A1
SCHEMBL10225715 0.80 LMNA (0.33) MAPTALDH1A1LMNAKMT2AMAOB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2173755-B1 NOVEL HERBICIDES SYNGENTA LTD (GB) 2017-05-17 EP disclosed