SCHEMBL188879

SCHEMBL188879

Nc1ccc(I)cc1F

nearest known ligand 0.00

⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Benzenethiol SCHEMBL8154426 0.84 ALDH1A1 (0.42)
SCHEMBL8943155 0.82 TDP1 (0.47)
SCHEMBL520223 0.79
SCHEMBL80458 0.75
SCHEMBL571047 0.75
SCHEMBL29481423 0.75
SCHEMBL29674842 0.75
Fluoride SCHEMBL25169957 0.72 CES2 (0.39)
SCHEMBL33738 0.72
SCHEMBL1277442 0.72

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1655 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-119707773-A Preparation method and application of maleimide structure-containing compound 中国农业大学 2025-03-28 CN claimed
CN-112827368-A Anti-pollution reverse osmosis membrane and preparation method thereof 中化(宁波)润沃膜科技有限公司 2021-05-25 CN claimed
CN-106045969-A Synthesis method of cobimetinib 湖南欧亚生物有限公司 2016-10-26 CN claimed
CN-102216274-A Process for making (r) -3-(2,3-dihydroxypropyl)-6-fluoro-5-(2-flouro-4-iodophenylamino)-8-methylpyrido[2,3-d]pyrimidine-4,7(3h,8h)-dione and intermediates thereof TAKEDA PHARMACEUTICAL 2011-10-12 CN claimed
EP-2358679-A2 PROCESS FOR MAKING (R) - 3-(2,3-DIHYDROXYPROPYL)-6-FLUORO-5-(2-FLUORO-4-IODOPHENYLAMINO)-8-METHYLPYRIDO [2,3-D] PYRIMIDINE-4,7 (3H,8H)-DIONE AND INTERMEDIATES THEREOF Takeda Pharmaceutical Company Limited (JP) 2011-08-24 EP claimed
WO-2010059503-A2 PROCESS FOR MAKING (R) -3-(2,3-DIHYDROXYPROPYL)-6-FLUORO-5-(2-FLOURO-4-IODOPHENYLAMINO)-8-METHYLPYRIDO[2,3-d]PYRIMIDINE-4,7(3H,8H)-DIONE AND INTERMEDIATES THEREOF TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) 2010-05-27 WO claimed
US-20100125138-A1 PROCESS FOR MAKING (R)-3-(2,3-DIHYDROXYPROPYL)-6-FLUORO-5-(2-FLOURO-4-IODOPHENYLAMINO)-8-METHYLPYRIDO[2,3-d]PYRIMIDINE-4,7(3H,8H)-DIONE AND INTERMEDIATES THEREOF TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) 2010-05-20 US claimed
JP-2007523865-A 2007-08-23 JP claimed
WO-2006134469-A1 METHODS OF PREPARING MEK INHIBITOR WARNER-LAMBERT COMPANY LLC (US) 2006-12-21 WO claimed
US-7129235-B2 Amides useful for treating pain ABBOTT LABORATORIES (US) 2006-10-31 US claimed
EP-1646621-A2 NOVEL AZAHETEROCYCLIC AMIDES USEFUL FOR TREATING PAIN Abbott Laboratories (US) 2006-04-19 EP claimed
US-20050080095-A1 administering a therapeuitcally effective amount of 3'-(trifluoromethyl)-N-{4-[(trifluoromethyl)sulfonyl]phenyl}-3,6-dihydro-2H-1,2'-bipyridine-4-carboxamide; antagonists of vanilloid receptor subtype I ABBVIE INC. 2005-04-14 US claimed
WO-2005007642-A2 NOVEL AZAHETEROCYCLIC AMIDES USEFUL FOR TREATING PAIN ABBOTT LABORATORIES (US) 2005-01-27 WO claimed
EP-4740942-A1 AROMATIC AMIDE DERIVATIVE AND USE THEREOF HUAJIAN FUTURE (CHENGDU) TECHNOLOGY CO., LTD. (CN) 2026-05-13 EP disclosed
EP-4725941-A1 ARYLAMIDE DERIVATIVE HAVING ANTITUMOR ACTIVITY CHUGAI SEIYAKU KABUSHIKI KAISHA (JP) 2026-04-15 EP disclosed
US-20260083690-A1 DISPERSIBLE FORMULATIONS OF N-((R)-2,3-DIHYDROXYPROPOXY)-3,4-DIFLUORO-2-(2- FLUORO-4-IODO-PHENYLAMINO)-BENAZMIDE AND USES THEREOF SPRINGWORKS THERAPEUTICS INC (US) 2026-03-26 US disclosed
EP-0442266-A1 Tolan derivatives, liquid crystal compositions containing them, and liquid crystal elements using them SEIKO EPSON CORPORATION (JP) 1991-08-21 EP disclosed
US-4564639-A INSECTICIDES TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) 1986-01-14 US disclosed
EP-0088343-B1 UREA DERIVATIVES, THEIR PRODUCTION AND USE Takeda Chemical Industries, Ltd. (JP) 1985-07-03 EP disclosed
EP-0088343-A2 Urea derivatives, their production and use Takeda Chemical Industries, Ltd. (JP) 1983-09-14 EP disclosed