SCHEMBL8943155

SCHEMBL8943155

Cc1ccc(F)c(N)c1.Nc1ccc(I)cc1F

nearest known ligand 0.47

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TDP1 Q9NUW8 2/20 0.47
ALOX15 P16050 2/20 0.47
CYP3A4 P08684 2/20 0.47
SMN1; SMN2 Q16637 2/20 0.47
TP53 P04637 1/20 0.47
THRB P10828 1/20 0.47
ALDH1A1 P00352 4/20 0.41
HSD17B10 Q99714 1/20 0.38
CA1 P00915 2/20 0.37
NPC1 O15118 2/20 0.37
RAB9A P51151 2/20 0.37
NFE2L2 Q16236 1/20 0.34
CA12 O43570 1/20 0.34
CA2 P00918 1/20 0.34
CA4 P22748 1/20 0.34
CA6 P23280 1/20 0.34
CA5A P35218 1/20 0.34
CA7 P43166 1/20 0.34
CA9 Q16790 1/20 0.34
CA14 Q9ULX7 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL59217 0.82
SCHEMBL188879 0.82
SCHEMBL17613 0.78
SCHEMBL520223 0.78
SCHEMBL29417984 0.78
SCHEMBL28749668 0.75 TDP1 (0.50) TDP1ALOX15CYP3A4SMN1; SMN2TP53
SCHEMBL28085288 0.73 TDP1 (0.48) TDP1ALOX15CYP3A4SMN1; SMN2TP53
SCHEMBL7363869 0.72 ALDH1A1 (0.57) TDP1ALOX15CYP3A4SMN1; SMN2TP53
Benzenethiol SCHEMBL8154426 0.69 ALDH1A1 (0.42) ALDH1A1CA1CA12CA2CA4
SCHEMBL14586542 0.67 TDP1 (0.48) TDP1ALOX15CYP3A4SMN1; SMN2TP53

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0710257-A1 IMIDO TRANSITION METAL COMPLEX METATHESIS CATALYSTS SHELL OIL CO (US) 1996-05-08 EP disclosed
WO-1995003346-A1 IMIDO TRANSITION METAL COMPLEX METATHESIS CATALYSTS SHELL OIL COMPANY (US) 1995-02-02 WO disclosed