Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 5/20 | 0.58 |
| ▸ | TP53 | P04637 | 5/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.58 |
| ▸ | HPGD | P15428 | 4/20 | 0.58 |
| ▸ | RAB9A | P51151 | 4/20 | 0.58 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.58 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.58 |
| ▸ | TSHR | P16473 | 2/20 | 0.58 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.58 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.58 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.58 |
| ▸ | RELA | Q04206 | 1/20 | 0.58 |
| ▸ | MEN1 | O00255 | 3/20 | 0.56 |
| ▸ | POLB | P06746 | 3/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.56 |
| ▸ | PKM | P14618 | 2/20 | 0.56 |
| ▸ | LMNA | P02545 | 1/20 | 0.56 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.54 |
| ▸ | USP2 | O75604 | 1/20 | 0.54 |
| ▸ | RUNX1 | Q01196 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18890607 | 0.89 | AMY1A (0.46) | NPC1TP53ALDH1A1HPGDRAB9A | |
| SCHEMBL18890545 | 0.82 | ALDH1A1 (0.58) | NPC1TP53ALDH1A1HPGDRAB9A | |
| SCHEMBL20982659 | 0.77 | NPC1 (0.85) | NPC1TP53ALDH1A1HPGDRAB9A | |
| SCHEMBL7037076 | 0.77 | CHEK2 (0.65) | NPC1TP53ALDH1A1HPGDRAB9A | |
| SCHEMBL18890639 | 0.76 | MMP2 (0.58) | NPC1TP53ALDH1A1HPGDRAB9A | |
| SCHEMBL18906383 | 0.76 | ALDH1A1 (0.55) | NPC1TP53ALDH1A1HPGDRAB9A | |
| SCHEMBL18890560 | 0.75 | RHEB (0.51) | NPC1TP53ALDH1A1HPGDRAB9A | |
| SCHEMBL3125413 | 0.75 | NPC1 (0.75) | NPC1TP53ALDH1A1HPGDRAB9A | |
| SCHEMBL29439014 | 0.74 | KDM4E (0.61) | NPC1TP53ALDH1A1HPGDRAB9A | |
| SCHEMBL4371528 | 0.74 | KDM4E (0.61) | NPC1TP53ALDH1A1HPGDRAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20170152245-A1 | BENZIMIDAZOLE COMPOUNDS AND THEIR APPLICATION IN CARDIOVASCULAR DISEASES | NATIONAL TAIWAN UNIVERSITY (TW) | 2017-06-01 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170152245-A1 | BENZIMIDAZOLE COMPOUNDS AND THEIR APPLICATION IN CARDIOVASCULAR DISEASES | TNNI3, PDGFRA, PDGFRB | NPC1 2699/4885TP53 4400/4885ALDH1A1 219/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.