Predicted protein targets (top 1)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOTUM | Q6P988 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8565151 | 0.79 | — | — | |
| SCHEMBL8558658 | 0.78 | CCNB2 (0.37) | — | |
| SCHEMBL10832750 | 0.76 | MEN1 (0.30) | — | |
| SCHEMBL8564117 | 0.74 | CCNB2 (0.41) | — | |
| SCHEMBL18894188 | 0.69 | PDCD1 (0.33) | — | |
| SCHEMBL8563838 | 0.69 | SIRT1 (0.30) | — | |
| SCHEMBL1886180 | 0.68 | PSMB8 (0.41) | — | |
| SCHEMBL28415698 | 0.67 | NOTUM (0.42) | NOTUM | |
| SCHEMBL18894175 | 0.66 | HPGD (0.36) | — | |
| SCHEMBL18894127 | 0.63 | CYP2D6 (0.31) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11136310-B2 | Iminotetrahydropyrimidinone derivatives as plasmepsin V inhibitors | UCB Biopharma SRL (BE) | 2021-10-05 | — | — | US | disclosed |
| US-20200283416-A1 | IMINOTETRAHYDROPYRIMIDINONE DERIVATIVES AS PLASMEPSIN V INHIBITORS | CELLTECH R&D LIMITED (GB) | 2020-09-10 | — | — | US | disclosed |
| US-10464932-B2 | Iminothiadiazinane dioxide derivatives as plasmepsin V inhibitors | UCB BIOPHARMA SPRL (BE) | 2019-11-05 | — | — | US | disclosed |
| US-20190040053-A1 | Iminothiadiazinane Dioxide Derivatives as Plasmepsin V Inhibitors | UCB BIOPHARMA SPRL (BE) | 2019-02-07 | — | — | US | disclosed |
| EP-3419975-A1 | IMINOTHIADIAZINANE DIOXIDE DERIVATIVES AS PLASMEPSIN V INHIBITORS | UCB Biopharma SPRL (BE) | 2019-01-02 | — | — | EP | disclosed |
| EP-3380464-A1 | IMINOTETRAHYDROPYRIMIDINONE DERIVATIVES AS PLASMEPSIN V INHIBITORS | UCB Biopharma SPRL (BE) | 2018-10-03 | — | — | EP | disclosed |
| WO-2017144517-A1 | IMINOTHIADIAZINANE DIOXIDE DERIVATIVES AS PLASMEPSIN V INHIBITORS | UCB BIOPHARMA SPRL (BE) | 2017-08-31 | — | — | WO | disclosed |
| WO-2017089453-A1 | IMINOTETRAHYDROPYRIMIDINONE DERIVATIVES AS PLASMEPSIN V INHIBITORS | UCB BIOPHARMA SPRL (BE) | 2017-06-01 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200283416-A1 | IMINOTETRAHYDROPYRIMIDINONE DERIVATIVES AS PLASMEPSIN V INHIBITORS | PEPD, ADAM17, ANPEP | NOTUM 1609/4885 |
| US-10464932-B2 | Iminothiadiazinane dioxide derivatives as plasmepsin V inhibitors | PEPD, CTSL, SERPINE1 | NOTUM 2522/4885 |
| US-11136310-B2 | Iminotetrahydropyrimidinone derivatives as plasmepsin V inhibitors | PEPD, ADAM17, ANPEP | NOTUM 1609/4885 |
| US-20190040053-A1 | Iminothiadiazinane Dioxide Derivatives as Plasmepsin V Inhibitors | PEPD, CTSL, SERPINE1 | NOTUM 2522/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.