Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 3/20 | 0.36 |
| ▸ | TSHR | P16473 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | HTR2A | P28223 | 1/20 | 0.33 |
| ▸ | HTR2C | P28335 | 1/20 | 0.33 |
| ▸ | HTR2B | P41595 | 1/20 | 0.33 |
| ▸ | DRD2 | P14416 | 1/20 | 0.32 |
| ▸ | DRD4 | P21917 | 1/20 | 0.32 |
| ▸ | DRD3 | P35462 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 2/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.31 |
| ▸ | NPC1 | O15118 | 1/20 | 0.31 |
| ▸ | TP53 | P04637 | 1/20 | 0.31 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.31 |
| ▸ | GFER | P55789 | 1/20 | 0.31 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.31 |
| ▸ | RELA | Q04206 | 1/20 | 0.31 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.30 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18894191 | 0.87 | ALOX15 (0.40) | HPGDTSHRALDH1A1RAB9ASMN1; SMN2 | |
| SCHEMBL16824178 | 0.81 | ROCK2 (0.33) | TSHRALDH1A1LMNARAB9ASMN1; SMN2 | |
| SCHEMBL10832750 | 0.72 | MEN1 (0.30) | LMNARAB9ASMN1; SMN2NPC1 | |
| SCHEMBL19283857 | 0.71 | KEAP1 (0.37) | ALDH1A1LMNAHTR2AHTR2CDRD2 | |
| SCHEMBL8563838 | 0.66 | SIRT1 (0.30) | — | |
| SCHEMBL18894139 | 0.66 | NOTUM (0.33) | — | |
| SCHEMBL31038046 | 0.66 | NOS1 (0.45) | ALDH1A1HTR2AHTR2CDRD2DRD4 | |
| SCHEMBL1886180 | 0.65 | PSMB8 (0.41) | LMNACYP1A2 | |
| SCHEMBL8564117 | 0.65 | CCNB2 (0.41) | GRM4 | |
| SCHEMBL27597298 | 0.64 | TERT (0.51) | ALDH1A1LMNARAB9ANPC1TP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11136310-B2 | Iminotetrahydropyrimidinone derivatives as plasmepsin V inhibitors | UCB Biopharma SRL (BE) | 2021-10-05 | — | — | US | disclosed |
| US-20200283416-A1 | IMINOTETRAHYDROPYRIMIDINONE DERIVATIVES AS PLASMEPSIN V INHIBITORS | CELLTECH R&D LIMITED (GB) | 2020-09-10 | — | — | US | disclosed |
| US-10464932-B2 | Iminothiadiazinane dioxide derivatives as plasmepsin V inhibitors | UCB BIOPHARMA SPRL (BE) | 2019-11-05 | — | — | US | disclosed |
| US-20190040053-A1 | Iminothiadiazinane Dioxide Derivatives as Plasmepsin V Inhibitors | UCB BIOPHARMA SPRL (BE) | 2019-02-07 | — | — | US | disclosed |
| EP-3419975-A1 | IMINOTHIADIAZINANE DIOXIDE DERIVATIVES AS PLASMEPSIN V INHIBITORS | UCB Biopharma SPRL (BE) | 2019-01-02 | — | — | EP | disclosed |
| EP-3380464-A1 | IMINOTETRAHYDROPYRIMIDINONE DERIVATIVES AS PLASMEPSIN V INHIBITORS | UCB Biopharma SPRL (BE) | 2018-10-03 | — | — | EP | disclosed |
| WO-2017144517-A1 | IMINOTHIADIAZINANE DIOXIDE DERIVATIVES AS PLASMEPSIN V INHIBITORS | UCB BIOPHARMA SPRL (BE) | 2017-08-31 | — | — | WO | disclosed |
| WO-2017089453-A1 | IMINOTETRAHYDROPYRIMIDINONE DERIVATIVES AS PLASMEPSIN V INHIBITORS | UCB BIOPHARMA SPRL (BE) | 2017-06-01 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200283416-A1 | IMINOTETRAHYDROPYRIMIDINONE DERIVATIVES AS PLASMEPSIN V INHIBITORS | PEPD, ADAM17, ANPEP | HPGD 571/4885TSHR 4748/4885ALDH1A1 3365/4885 |
| US-10464932-B2 | Iminothiadiazinane dioxide derivatives as plasmepsin V inhibitors | PEPD, CTSL, SERPINE1 | HPGD 557/4885TSHR 3412/4885ALDH1A1 2865/4885 |
| US-11136310-B2 | Iminotetrahydropyrimidinone derivatives as plasmepsin V inhibitors | PEPD, ADAM17, ANPEP | HPGD 571/4885TSHR 4748/4885ALDH1A1 3365/4885 |
| US-20190040053-A1 | Iminothiadiazinane Dioxide Derivatives as Plasmepsin V Inhibitors | PEPD, CTSL, SERPINE1 | HPGD 557/4885TSHR 3412/4885ALDH1A1 2865/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.