Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 4/20 | 0.40 |
| ▸ | HTR1A | P08908 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.35 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.35 |
| ▸ | DRD2 | P14416 | 2/20 | 0.35 |
| ▸ | DRD3 | P35462 | 1/20 | 0.35 |
| ▸ | HTR7 | P34969 | 1/20 | 0.34 |
| ▸ | HSPA9 | P38646 | 1/20 | 0.34 |
| ▸ | DRD4 | P21917 | 1/20 | 0.34 |
| ▸ | HTR2B | P41595 | 1/20 | 0.34 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.33 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7615965 | 0.78 | HTR1A (0.35) | SIGMAR1HTR1AMEN1ALDH1A1KMT2A | |
| SCHEMBL10287635 | 0.71 | CCR1 (0.49) | HTR1AALDH1A1HRH3DRD2DRD3 | |
| SCHEMBL10702160 | 0.70 | HTR2B (0.40) | SIGMAR1HTR1AMEN1ALDH1A1LMNA | |
| SCHEMBL10699642 | 0.69 | EDNRB (0.41) | SIGMAR1HTR1AMEN1ALDH1A1KMT2A | |
| SCHEMBL12121748 | 0.68 | CCR1 (0.37) | DRD2DRD3DRD4 | |
| SCHEMBL8800043 | 0.68 | DRD2 (0.36) | SIGMAR1HTR1AMEN1ALDH1A1KMT2A | |
| SCHEMBL10287667 | 0.68 | CCR1 (0.54) | SIGMAR1MEN1ALDH1A1LMNAKMT2A | |
| SCHEMBL8797672 | 0.67 | EDNRB (0.46) | MEN1ALDH1A1KMT2ADRD2DRD3 | |
| SCHEMBL7205528 | 0.67 | CCR1 (0.49) | KMT2AOPRM1OPRD1 | |
| SCHEMBL7205522 | 0.67 | CCR1 (0.49) | KMT2AOPRM1OPRD1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9663537-B2 | Chemokine receptor antagonists and methods of use | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2017-05-30 | — | — | US | disclosed |