Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 2/20 | 0.35 |
| ▸ | HTR2B | P41595 | 2/20 | 0.35 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.35 |
| ▸ | HTR2A | P28223 | 4/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.35 |
| ▸ | MAPT | P10636 | 3/20 | 0.35 |
| ▸ | GAA | P10253 | 2/20 | 0.35 |
| ▸ | HPGD | P15428 | 2/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | DRD2 | P14416 | 1/20 | 0.34 |
| ▸ | DRD3 | P35462 | 1/20 | 0.34 |
| ▸ | EDNRB | P24530 | 1/20 | 0.34 |
| ▸ | EDNRA | P25101 | 1/20 | 0.34 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.34 |
| ▸ | HTR7 | P34969 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10699642 | 0.79 | EDNRB (0.41) | HTR1AHTR2BSIGMAR1HTR2AALDH1A1 | |
| SCHEMBL10702160 | 0.78 | HTR2B (0.40) | HTR1AHTR2BSIGMAR1HTR2AALDH1A1 | |
| SCHEMBL18895992 | 0.78 | SIGMAR1 (0.40) | HTR1AHTR2BSIGMAR1ALDH1A1DRD2 | |
| SCHEMBL8800043 | 0.76 | DRD2 (0.36) | HTR1AHTR2BSIGMAR1ALDH1A1MAPT | |
| SCHEMBL7209964 | 0.75 | EDNRB (0.36) | HTR1AHTR2BSIGMAR1ALDH1A1MAPT | |
| SCHEMBL8797672 | 0.75 | EDNRB (0.46) | ALDH1A1MAPTGAAHPGDTDP1 | |
| SCHEMBL2215953 | 0.70 | HTR2A (0.55) | HTR1AHTR2BSIGMAR1HTR2AALDH1A1 | |
| SCHEMBL2217095 | 0.70 | HTR2A (0.55) | HTR2AALDH1A1MAPTGAAHPGD | |
| SCHEMBL7210858 | 0.70 | ALDH1A1 (0.42) | HTR1AHTR2BSIGMAR1HTR2AALDH1A1 | |
| SCHEMBL7210855 | 0.70 | ALDH1A1 (0.42) | HTR1AHTR2BSIGMAR1HTR2AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6433165-B1 | ANTIINFLAMMATORY AGENTS | MILLENNIUM PHARMACEUTICALS, INC. | 2002-08-13 | — | — | US | disclosed |