Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KIF11 | P52732 | 5/20 | 0.49 |
| ▸ | ROCK2 | O75116 | 5/20 | 0.48 |
| ▸ | GABRA1 | P14867 | 3/20 | 0.48 |
| ▸ | GABRG2 | P18507 | 3/20 | 0.48 |
| ▸ | GABRB3 | P28472 | 3/20 | 0.48 |
| ▸ | GABRA5 | P31644 | 3/20 | 0.48 |
| ▸ | GABRA3 | P34903 | 3/20 | 0.48 |
| ▸ | GABRA2 | P47869 | 3/20 | 0.48 |
| ▸ | GABRP | O00591 | 2/20 | 0.48 |
| ▸ | GABRD | O14764 | 2/20 | 0.48 |
| ▸ | GABRB1 | P18505 | 2/20 | 0.48 |
| ▸ | GABRB2 | P47870 | 2/20 | 0.48 |
| ▸ | GABRA4 | P48169 | 2/20 | 0.48 |
| ▸ | GABRE | P78334 | 2/20 | 0.48 |
| ▸ | GABRA6 | Q16445 | 2/20 | 0.48 |
| ▸ | GABRG1 | Q8N1C3 | 2/20 | 0.48 |
| ▸ | GABRG3 | Q99928 | 2/20 | 0.48 |
| ▸ | GABRQ | Q9UN88 | 2/20 | 0.48 |
| ▸ | ACHE | P22303 | 1/20 | 0.41 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18901227 | 0.83 | GABRP (0.50) | KIF11ROCK2GABRA1GABRG2GABRB3 | |
| SCHEMBL28050860 | 0.77 | KIF11 (0.56) | KIF11GABRA1GABRG2GABRB3GABRA5 | |
| SCHEMBL16345630 | 0.76 | ROCK2 (0.62) | KIF11ROCK2 | |
| SCHEMBL2628365 | 0.73 | ACHE (0.59) | KIF11GABRA1GABRG2GABRB3GABRA5 | |
| SCHEMBL4256780 | 0.72 | KIF11 (0.78) | KIF11GABRA1GABRG2GABRB3GABRA5 | |
| SCHEMBL29518339 | 0.72 | KIF11 (0.78) | KIF11GABRA1GABRG2GABRB3GABRA5 | |
| SCHEMBL1798677 | 0.71 | CHUK (0.55) | ROCK2GABRA1GABRG2GABRB3GABRA5 | |
| SCHEMBL23369904 | 0.70 | KIF11 (0.82) | KIF11ACHERXFP1 | |
| SCHEMBL18901304 | 0.69 | KIF11 (0.58) | KIF11ROCK2GABRA1GABRG2GABRB3 | |
| SCHEMBL2628321 | 0.69 | GABRP (0.49) | KIF11GABRA1GABRG2GABRB3GABRA5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3016951-B1 | TRICYCLIC PYRIDO-CARBOXAMIDE DERIVATIVES AS ROCK INHIBITORS | BRISTOL MYERS SQUIBB CO (US) | 2017-05-31 | — | — | EP | disclosed |